P. Therese Lang

University of California, Berkeley — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index3.2kcitations16works0.02yr avg
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Research Topics

Protein Structure and Dynamics(6), Enzyme Structure and Function(6), Computational Drug Discovery Methods(4), RNA and protein synthesis mechanisms(3), Biochemical and Molecular Research(3)

Publications16 total

DOCK 6: Impact of new features and current docking performance
Journal of Computational Chemistry·2015· 818 citedOpen Access
High Throughput Computing Validation for Drug Discovery Using the DOCK Program on a Massively Parallel System
2015· 11 cited
Protein structural ensembles are revealed by redefining X-ray electron density noise
Proceedings of the National Academy of Sciences·2013· 93 citedOpen Access
Cyclic AMP regulation of protein lysine acetylation in Mycobacterium tuberculosis
Nature Structural & Molecular Biology·2012· 60 cited
Crystal structure of protein lysine acetyltransferase Rv0998 in complex with acetyl CoA and cAMP
2012
Accessing protein conformational ensembles using room-temperature X-ray crystallography
Proceedings of the National Academy of Sciences·2011· 639 cited
Backdoor opening mechanism in acetylcholinesterase based on X‐ray crystallography and molecular dynamics simulations
Protein Science·2011· 69 citedOpen Access
Automated electron‐density sampling reveals widespread conformational polymorphism in proteins
Protein Science·2010· 181 citedOpen Access
Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA
Bioorganic & Medicinal Chemistry Letters·2009· 51 citedOpen Access
DOCK 6: Combining techniques to model RNA–small molecule complexes
RNA·2009· 743 citedOpen Access
FeynEdit—a tool for drawing Feynman diagrams
Computer Physics Communications·2008· 9 citedOpen Access
Development and validation of a modular, extensible docking program: DOCK 5
Journal of Computer-Aided Molecular Design·2006· 436 cited
Molecular Docking and Structure‐Based Design
2006· 2 cited
Synthesis and Testing of a Focused Phenothiazine Library for Binding to HIV-1 TAR RNA
Chemistry & Biology·2006· 76 cited
Modeling Small Molecule‐RNA Interactions: Applications to HIV TAR RNA
The FASEB Journal·2006
Evaluating the High-Throughput Screening Computations
SLAS DISCOVERY·2005· 20 citedOpen Access

Frequent Co-authors

Irwin D. Kuntz(6), Tom Alber(6), Robert C. Rizzo(3), Thomas Leroy James(3), James S. Fraser(3), James M. Holton(3), Sudipto Mukherjee(2), Scott R. Brozell(2), David A. Case(2), Eric F. Pettersen(2), Nathaniel Echols(2), Demetri T. Moustakas(2), Natasja Brooijmans(2), R. Kiplin Guy(2), Sarah M. Fortune(2), Christopher M. Sassetti(2), William J. Allen(1), Trent E. Balius(1), Demetri Moustakas(1), Elaine C. Meng(1)