David Farley

Oxford BioMedica (United Kingdom) — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

15h-index1.7kcitations41works2.02yr avg
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Research Topics

Protease and Inhibitor Mechanisms(10), Peptidase Inhibition and Analysis(5), Cell Adhesion Molecules Research(4), Enzyme Production and Characterization(3), Oral microbiology and periodontitis research(2)

Publications41 total

Risks of replication-competent retro/lentivirus from associated vector systems: Is it time for a roadmap toward reduced testing?
Molecular Therapy — Methods & Clinical Development·2025· 3 citedOpen Access
THE TETRAVECTA™ SYSTEM: A NEW TOOL KIT ENHANCING LENTIVIRAL VECTOR PRODUCTION FOR THE NEXT GENERATION OF GENE THERAPIES
Cytotherapy·2024· 1 cited
In-Depth Characterization and Validation in <i>BRG1</i> -Mutant Lung Cancers Define Novel Catalytic Inhibitors of SWI/SNF Chromatin Remodeling
2019· 9 citedOpen Access
Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers
Journal of Medicinal Chemistry·2018· 225 citedOpen Access
Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening
Journal of Visualized Experiments·2018· 10 citedOpen Access
Metabolic Enzyme Sulfotransferase 1A1 Is the Trigger for N-Benzyl Indole Carbinol Tumor Growth Suppression
Chemistry & Biology·2015· 14 cited
Abstract B38: Inhibiting mutated KRAS, a broken switch of effector pathways
Molecular Cancer Research·2014
Reoperation for open and laparoscopic groin hernia
Jaypee Brothers Medical Publishers (P) Ltd. eBooks·2014
Discovery of Potent, Selective, and Orally Active Carboxylic Acid Based Inhibitors of Matrix Metalloproteinase-13
Journal of Medicinal Chemistry·2009· 56 citedOpen Access
It will be back: 2004 West Nile Virus activities in Fresno County, California.
2004
N-Arylaminonitriles as bioavailable peptidomimetic inhibitors of cathepsin B
Bioorganic & Medicinal Chemistry Letters·2003· 28 citedOpen Access
Linked Deficiencies in Extracellular PPi and Osteopontin Mediate Pathologic Calcification Associated With Defective PC-1 and ANK Expression
Journal of Bone and Mineral Research·2003· 198 citedOpen Access
Development of an Assay Suitable for High-Throughput Screening to Measure Matrix Metalloprotease Activity
Assay and Drug Development Technologies·2003· 14 cited
One of two chondrocyte‐expressed isoforms of cartilage intermediate‐layer protein functions as an insulin‐like growth factor 1 antagonist
Arthritis & Rheumatism·2003· 74 citedOpen Access
Arylaminoethyl Amides as Novel Non-Covalent Cathepsin K Inhibitors
Journal of Medicinal Chemistry·2002· 44 citedOpen Access
Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design
Journal of Medicinal Chemistry·2001· 136 citedOpen Access
Cathepsin B complexed with dipeptidyl nitrile inhibitor
2001
Purification, Characterization, and Sequence Analysis of a Potential Virulence Factor from <i>Porphyromonas gingivalis</i> , Peptidylarginine Deiminase
Infection and Immunity·1999· 370 citedOpen Access
Finasteride: A slow-binding 5.alpha.-reductase inhibitor
Biochemistry·1993· 78 cited
Cloning and sequence analysis of rat hepsin, a cell surface serine proteinase
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression·1993· 10 cited
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Frequent Co-authors

Guy S. Salvesen(5), Kirk Clark(4), Rubén Tommasi(4), Leslie W. McQuire(4), Andrew M. Wigg(4), John Doughty(4), James Travis(3), Raviraj Kulathila(3), Paul D. Greenspan(3), Scott D. Cowen(3), John J. Fitt(3), David E. Coppa(3), William Macchia(3), Hanspeter Nick(3), Julien P. N. Papillon(2), Katsumasa Nakajima(2), Christopher D. Adair(2), Simon Mathieu(2), Rukundo Ntaganda(2), Troy Smith(2)