Lakshman Sandirasegarane

Medicine · Health Sciences

14h-index2.2kcitations23works0.02yr avg
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Research Topics

Nitric Oxide and Endothelin Effects(9), Protein Kinase Regulation and GTPase Signaling(6), Receptor Mechanisms and Signaling(6), PI3K/AKT/mTOR signaling in cancer(5), Retinal Diseases and Treatments(4)

Publications23 total

Imatinib induces apoptosis by inhibiting PDGF- but not insulin-induced PI 3-kinase/Akt survival signaling in RGC-5 retinal ganglion cells.
PubMed·2009· 22 cited
Ether-linked diglycerides inhibit vascular smooth muscle cell growth via decreased MAPK and PI3K/Akt signaling
American Journal of Physiology-Heart and Circulatory Physiology·2008· 11 citedOpen Access
PDGF- and Insulin/IGF-1–Specific Distinct Modes of Class I<sub>A</sub>PI 3-Kinase Activation in Normal Rat Retinas and RGC-5 Retinal Ganglion Cells
Investigative Ophthalmology & Visual Science·2008· 27 cited
Human fetal cardiac myocyte growth is mediated by activation of class 1A/1B pi 3-kinase, Akt, PKC, and ERK signaling
Journal of Molecular and Cellular Cardiology·2007
Diabetic Retinopathy
Diabetes·2006· 726 cited
Diabetes Reduces Basal Retinal Insulin Receptor Signaling
Diabetes·2006· 167 citedOpen Access
Deregulated Akt3 Activity Promotes Development of Malignant Melanoma
Cancer Research·2004· 576 cited
Pertussis Toxin-Sensitive G Protein but Not NO/cGMP Pathway Mediates the Negative Inotropic Effect of Carbachol in Adult Rat Cardiomyocytes
Pharmacology·2003· 5 cited
Characterization of insulin signaling in rat retina in vivo and ex vivo
American Journal of Physiology-Endocrinology and Metabolism·2003· 107 cited
Ceramide-induced Inhibition of Akt Is Mediated through Protein Kinase Cζ
Journal of Biological Chemistry·2002· 241 citedOpen Access
Therapeutic Implications of Ceramide-Regulated Signaling Cascades
Molecular biology intelligence unit·2002
Enhanced Stimulation of Akt-3/Protein Kinase B-γ in Human Aortic Smooth Muscle Cells
Biochemical and Biophysical Research Communications·2001· 36 cited
Ceramide-Coated Balloon Catheters Limit Neointimal Hyperplasia After Stretch Injury in Carotid Arteries
Circulation Research·2000· 60 citedOpen Access
NO regulates PDGF-induced activation of PKB but not ERK in A7r5 cells: implications for vascular growth arrest
American Journal of Physiology-Cell Physiology·2000· 42 cited
The Nitric Oxide Donors, SNAP and DEA/NO, Exert a Negative Inotropic Effect in Rat Cardiomyocytes which is Independent of Cyclic GMP Elevation
Journal of Molecular and Cellular Cardiology·1999· 40 cited
Enhanced forebrain nitric oxide synthase activity in epileptic fowl
Brain Research·1996· 14 cited
Alterations in inotropy, nitric oxide and cyclic GMP synthesis, protein phosphorylation and ADP-ribosylation in the endotoxin-treated rat myocardium and cardiomyocytes
Molecular and Cellular Biochemistry·1996· 15 cited
Alterations in inotropy, nitric oxide and cyclic GMP synthesis, protein phosphorylation and ADP-ribosylation in the endotoxin-treated rat myocardium and cardiomyocytes
1996· 2 cited
Vanadate increases cytosolic free calcium in rat aortic smooth muscle cells
Life Sciences·1995· 19 cited
High Glucose Attenuates Peptide Agonist-Evoked Increases in Cytosolic Free [Ca2+] in Rat Aortic Smooth Muscle Cells
Diabetes·1994· 13 cited
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Frequent Co-authors

Mark Kester(9), Thomas W. Gardner(4), Venkat Gopalakrishnan(4), David A. Antonetti(3), Nicole A. Bourbon(3), Swarajit Kumar Biswas(3), Prakash V. Sulakhe(3), Alistair J. Barber(2), Ian A. Simpson(2), Chad E.N. Reiter(2), Roger Charles(2), Jong K. Yun(2), Jack Diamond(2), Yan Zhao(2), John P. Davis(2), Xuan T. Vo(2), Willard J. Costain(2), Rahul Mainra(2), Sarah K. Bronson(1), Willard M. Freeman(1)