Line Ledsgaard

Technical University of Denmark — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index1.1kcitations31works5.62yr avg
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Research Topics

Venomous Animal Envenomation and Studies(19), Monoclonal and Polyclonal Antibodies Research(11), Toxin Mechanisms and Immunotoxins(11), Rabies epidemiology and control(7), Biochemical and Structural Characterization(6)

Publications31 total

Section-level genome sequencing and comparative genomics of <i>Aspergillus</i> sections <i>Cavernicolus</i> and <i>Usti</i>
Studies in Mycology·2025Open Access
Section-level genome sequencing and comparative genomics of Aspergillus sections Cavernicolus and Usti
Studies in Mycology·2025Open Access
Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling
Structure·2024· 6 citedOpen Access
Genomic Analysis of Aspergillus Section Terrei Reveals a High Potential in Secondary Metabolite Production and Plant Biomass Degradation
Journal of Fungi·2024· 6 citedOpen Access
Antibody-dependent enhancement of toxicity of myotoxin II from Bothrops asper
Nature Communications·2024· 16 citedOpen Access
Phage display assisted discovery of a <scp>pH</scp> ‐dependent anti‐α‐cobratoxin antibody from a natural variable domain library
Protein Science·2023· 13 citedOpen Access
An in vitro assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules
Biochemical Pharmacology·2023· 9 citedOpen Access
Cross-reactivity trends when selecting scFv antibodies against snake toxins using a phage display-based cross-panning strategy
Scientific Reports·2023· 12 citedOpen Access
Phage display assisted discovery of a pH-dependent anti-α-cobratoxin antibody from a natural variable domain library
2023· 1 citedOpen Access
An <i>in vitro</i> assay to investigate venom neurotoxin activity on muscle-type nicotinic acetylcholine receptor activation and for the discovery of toxin-inhibitory molecules
2023Open Access
Discovery and optimization of a broadly-neutralizing human monoclonal antibody against long-chain α-neurotoxins from snakes
Nature Communications·2023· 63 citedOpen Access
Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes
Bioconjugate Chemistry·2022· 31 citedOpen Access
Discovery of a broadly-neutralizing human antibody that can rescue mice challenged with neurotoxin-rich snake venoms
2022· 2 citedOpen Access
<i>In vitro</i> discovery of a human monoclonal antibody that neutralizes lethality of cobra snake venom
mAbs·2022· 41 citedOpen Access
Advances in antibody phage display technology
Drug Discovery Today·2022· 133 citedOpen Access
Synthetic antibodies block receptor binding and current‐inhibiting effects of α‐cobratoxin from <i>Naja kaouthia</i>
Protein Science·2022· 13 citedOpen Access
Orally active bivalent VHH construct prevents proliferation of F4+ enterotoxigenic Escherichia coli in weaned piglets
iScience·2022· 25 citedOpen Access
In vitro discovery and optimization of a human monoclonal antibody that neutralizes neurotoxicity and lethality of cobra snake venom
2021· 4 citedOpen Access
Cross-Reactive SARS-CoV-2 Neutralizing Antibodies From Deep Mining of Early Patient Responses
Frontiers in Immunology·2021· 28 citedOpen Access
Deep mining of early antibody response in COVID-19 patients yields potent neutralisers and reveals high level of convergence
2020· 3 citedOpen Access
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Frequent Co-authors

Andreas H. Laustsen(26), Aneesh Karatt-Vellatt(10), Bruno Lomonte(9), Christoffer V. Sørensen(9), Shirin Ahmadi(8), Anne Ljungars(7), Jack Wade(7), Mikael Rørdam Andersen(6), Manuela B. Pucca(6), Timothy P. Jenkins(6), Kim Boddum(6), Primitivo Caballero(6), Rachael A. Leah(6), José Marı́a Gutiérrez(5), Felipe A. Cerni(5), Tulika Tulika(5), Björn G. Voldborg(5), Markus‐Frederik Bohn(5), John McCafferty(4), Urška Puš(4)