C. Hugh Reynolds

Medicine · Health Sciences

28h-index4.1kcitations47works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(21), Microtubule and mitosis dynamics(7), Enzyme function and inhibition(7), Hemoglobin structure and function(5), Biochemical and Molecular Research(5)

Publications47 total

Transcriptomic analysis of oligomeric amyloid-β treated primary cortical neurons reveals dysregulation of genes involved in the biosynthesis of steroids and cholesterol
Research Portal (King's College London)·2014
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
Molecular Psychiatry·2012· 230 citedOpen Access
Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons
Neurochemistry International·2012· 26 cited
Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau
FEBS Journal·2011· 89 cited
Tyrosine Phosphorylation of Tau by the Src Family Kinases Lck and Fyn
Molecular Neurodegeneration·2011· 52 citedOpen Access
The Microtubule-Associated Protein Tau is Also Phosphorylated on Tyrosine
Journal of Alzheimer s Disease·2009· 86 cited
Transmembrane Helix 12 Modulates Progression of the ATP Catalytic Cycle in ABCB1
Biochemistry·2009· 32 citedOpen Access
Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases
Journal of Biological Chemistry·2008· 218 citedOpen Access
The microtubule-associated protein tau is phosphorylated by Syk
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2007· 56 citedOpen Access
Novel Phosphorylation Sites in Tau from Alzheimer Brain Support a Role for Casein Kinase 1 in Disease Pathogenesis
Journal of Biological Chemistry·2007· 457 citedOpen Access
GSK3α exhibits β‐catenin and tau directed kinase activities that are modulated by Wnt
European Journal of Neuroscience·2006· 64 cited
Tyrosine 394 Is Phosphorylated in Alzheimer's Paired Helical Filament Tau and in Fetal Tau with c-Abl as the Candidate Tyrosine Kinase
Journal of Neuroscience·2005· 184 citedOpen Access
Tau Phosphorylation Both In Vitro and in Cells
Humana Press eBooks·2003· 5 cited
Tyrosine phosphorylation of specific sites on tau by src family kinases
Queensland's institutional digital repository (The University of Queensland)·2002
Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases
Journal of Neuroscience·2002· 227 citedOpen Access
Sites of phosphorylation in tau and factors affecting their regulation
Biochemical Society Symposia·2001· 97 cited
Phosphorylation Sites on Tau Identified by Nanoelectrospray Mass Spectrometry
Journal of Neurochemistry·2000· 359 cited
Reactivating Kinase/p38 Phosphorylates τ Protein In Vitro
Journal of Neurochemistry·1997· 166 cited
Phosphorylation of tau by glycogen synthase kinase 3<i>β</i> affects the ability of tau to promote microtubule self-assembly
Biochemical Journal·1997· 84 citedOpen Access
Oxidative Stress Induces Dephosphorylation of τ in Rat Brain Primary Neuronal Cultures
Journal of Neurochemistry·1997· 52 cited
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Frequent Co-authors

Brian H. Anderton(20), Diane P. Hanger(11), Simon Lovestone(9), Ritchie Williamson(8), Stuart Kellie(8), John S. McKinley-McKee(8), Graham Gibb(7), Jean‐Pierre Brion(6), Keith Dalziel(6), Jean‐Marc Gallo(5), Timothy M.E. Scales(5), Pascal Derkinderen(5), Christopher C.J. Miller(4), Helen L. Byers(4), Kit‐Yi Leung(4), Malcolm Ward(4), Richard Killick(4), Alessia Usardi(4), Wendy Noble(4), Ian N. Bird(4)