Frances M. G. Pearl

University of Sussex — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index4.0kcitations63works3.32yr avg
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Research Topics

Protein Structure and Dynamics(15), Genomics and Phylogenetic Studies(14), Enzyme Structure and Function(13), RNA and protein synthesis mechanisms(12), Bioinformatics and Genomic Networks(12)

Publications63 total

P05.05.A INTEGRATED MULTI-OMICS AND MULTI-SPECTRAL PROFILING OF PLASMA EXTRACELLULAR VESICLES REVEALS HIGHLY ACCURATE LIQUID BIOPSY BIOMARKERS FOR GLIOMA DIAGNOSIS.
Neuro-Oncology·2025Open Access
DEVELOPING AN EXTRACELLULAR VESICLE-BASED MULTI-OMIC LIQUID BIOPSY BIOMARKER SIGNATURE OF GLIOMA USING SAMPLES FROM THE GENOMICS ENGLAND BIOBANK
Neuro-Oncology·2025Open Access
Using Cancer Profiles to Identify Synthetic Lethal Therapeutic Targets and Predictive Biomarkers in Cancer Gene Dependency Data
2025
Identifying actionable synthetically lethal cancer gene pairs using mutual exclusivity
FEBS Letters·2024· 3 citedOpen Access
Kinome‐Wide Synthetic Lethal Screen Identifies PANK4 as a Modulator of Temozolomide Resistance in Glioblastoma
Advanced Science·2024· 7 citedOpen Access
A brain metastasis liquid biopsy: Where are we now?
Neuro-Oncology Advances·2024· 10 citedOpen Access
Kinome-wide synthetic lethal screen identifies PANK4 as modulator of resistance in glioblastoma 
Research Square (Research Square)·2023Open Access
A combined bioinformatics and LC-MS-based approach for the development and benchmarking of a comprehensive database of <i>Lymnaea</i> CNS proteins
Journal of Experimental Biology·2022· 6 citedOpen Access
Aneuploidy tolerance caused by BRG1 loss allows chromosome gains and recovery of fitness
Nature Communications·2022· 18 citedOpen Access
Biological network topology features predict gene dependencies in cancer cell-lines
Bioinformatics Advances·2022· 5 citedOpen Access
A combined bioinformatics and LC-MS based approach for the development and benchmarking of a comprehensive database for CNS proteins in <i>Lymnaea stagnalis</i>
2021Open Access
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
eLife·2021· 30 citedOpen Access
Author response: Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
2021Open Access
Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein
2020Open Access
PIK3Cδ expression by fibroblasts promotes triple-negative breast cancer progression
Journal of Clinical Investigation·2020· 50 citedOpen Access
Defining Signatures of Arm-Wise Copy Number Change and Their Associated Drivers in Kidney Cancers
International Journal of Molecular Sciences·2019· 10 citedOpen Access
Global kinome silencing combined with 3D invasion screening of the tumor microenvironment identifies fibroblast-expressed PIK3Cδ involvement in triple-negative breast cancer progression
2019Open Access
Biological network topology features predict gene dependencies in cancer cell lines
2019· 5 citedOpen Access
Identifying the Impact of Inframe Insertions and Deletions on Protein Function in Cancer
Journal of Computational Biology·2019· 3 cited
Cell-derived extracellular vesicles can be used as a biomarker reservoir for glioblastoma tumor subtyping
Communications Biology·2019· 99 citedOpen Access
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Frequent Co-authors

Christine Orengo(16), Janet M. Thornton(14), Graeme Benstead-Hume(13), Sarah K. Wooller(10), Annabel E. Todd(7), Laurence H. Pearl(6), James E. Bray(6), Ian Sillitoe(6), Andrew Harrison(4), Jessica A. Downs(4), Georgios Giamas(4), Daniel Buchan(4), Simon E. Ward(3), Oliver Redfern(3), Xiangrong Chen(3), Justin Stebbing(3), David Lee(3), Christopher Richardson(3), Hanadi M. Baeissa(3), Lesley H. Greene(2)