John L. Neumeyer

Harvard University — United States

Neuroscience · Life Sciences

45h-index8.5kcitations358works0.02yr avg
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Research Topics

Neurotransmitter Receptor Influence on Behavior(63), Receptor Mechanisms and Signaling(60), Traditional and Medicinal Uses of Annonaceae(57), Neuroscience and Neuropharmacology Research(40), Neuropeptides and Animal Physiology(37)

Publications357 total

The Non-Anhydrous, Minimally Basic Synthesis of the Dopamine D2 Agonist [18F]MCL-524
Chemistry·2021· 2 citedOpen Access
The High Affinity Dopamine D<sub>2</sub> Receptor Agonist MCL-536: A New Tool for Studying Dopaminergic Contribution to Neurological Disorders
ACS Chemical Neuroscience·2021· 7 citedOpen Access
A non-anhydrous, minimally basic protocol for the simplification of nucleophilic 18F-fluorination chemistry
Scientific Reports·2020· 26 citedOpen Access
Identification of fluorinated (R)-(−)-aporphine derivatives as potent and selective ligands at serotonin 5-HT2C receptor
Bioorganic & Medicinal Chemistry Letters·2018· 9 citedOpen Access
New Dopamine D2 Receptor Agonist, [<sup>3</sup>H]MCL-536, for Detecting Dopamine D2high Receptors in Vivo
ACS Chemical Neuroscience·2018· 6 citedOpen Access
Oral r‐(‐)‐11‐o‐valeryl‐n‐<i>n</i>‐propylnoraporphine reverses motor deficits in mptp‐treated marmosets
Movement Disorders·2016· 8 cited
18F chemistry without azeotropic distillations: tetraethylammonium salts as combined anion exchange reagents and phase transfer catalysts.
2016· 4 cited
Convenient synthesis of <sup>18</sup>F‐radiolabeled R‐(−)‐N‐<i>n</i>‐propyl‐2‐(3‐fluoropropanoxy‐11‐hydroxynoraporphine
Journal of Labelled Compounds and Radiopharmaceuticals·2014· 6 citedOpen Access
Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with κ agonist and μ agonist/antagonist activity
European Journal of Pharmacology·2014· 7 cited
A mixed kappa/mu partial opioid agonist attenuated cocaine-induced locomotion
Drug and Alcohol Dependence·2014· 1 cited
<sup>18</sup>F-MCL-524, an<sup>18</sup>F-Labeled Dopamine D<sub>2</sub>and D<sub>3</sub>Receptor Agonist Sensitive to Dopamine: A Preliminary PET Study
Journal of Nuclear Medicine·2014· 21 citedOpen Access
Preliminary Pharmacological Evaluation of Enantiomeric Morphinans
ACS Chemical Neuroscience·2014· 21 citedOpen Access
Synthesis and Pharmacological Evaluation of Aminothiazolomorphinans at the Mu and Kappa Opioid Receptors
Journal of Medicinal Chemistry·2013· 22 citedOpen Access
Update 1 of: Recent Progress in Development of Dopamine Receptor Subtype-Selective Agents: Potential Therapeutics for Neurological and Psychiatric Disorders
Chemical Reviews·2013· 87 cited
[18F]MCL-524, an 18F-labeled dopamine D2/D3 receptors agonist radioligand with higher binding signal than [11C]MNPA
2012· 1 cited
Synthesis, Binding Affinity, and Functional in Vitro Activity of 3-Benzylaminomorphinan and 3-Benzylaminomorphine Ligands at Opioid Receptors
Journal of Medicinal Chemistry·2012· 13 citedOpen Access
A Tribute to Joseph G. Cannon, 1926–2011
Journal of Medicinal Chemistry·2012
Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for κ, μ, and δ opioid receptors
Bioorganic & Medicinal Chemistry·2011· 24 citedOpen Access
Aminothiazolomorphinans with Mixed κ and μ Opioid Activity
Journal of Medicinal Chemistry·2011· 21 citedOpen Access
Synthesis and Evaluation of Fluorinated Aporphines: Potential Positron Emission Tomography Ligands for D<sub>2</sub> Receptors
ACS Medicinal Chemistry Letters·2011· 18 citedOpen Access
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Frequent Co-authors

Richard A. Milius(10), Yolanda Zea‐Ponce(9), Ronald M. Baldwin(8), Shaoyin Wang(8), Sami S. Zoghbi(7), Robert B. Innis(7), Jean M. Bidlack(7), Ross J. Baldessarini(6), Nora S. Kula(5), E. Sybirska(4), Dennis S. Charney(4), Paul B. Hoffer(4), Yigong Gao(4), Brian I. Knapp(4), Ao Zhang(3), Marc Laruelle(3), Eileen O. Smith(3), Marc Laruelle(3), Elizabeth A. Wallace(3), John Seibyl(3)