David Neuhaus

MRC Laboratory of Molecular Biology — United Kingdom

Biochemistry, Genetics and Molecular Biology · Life Sciences

49h-index8.0kcitations159works0.52yr avg
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Research Topics

RNA and protein synthesis mechanisms(24), RNA Research and Splicing(23), Advanced NMR Techniques and Applications(18), RNA modifications and cancer(16), Protein Structure and Dynamics(15)

Publications159 total

A finger that gets in the way: When binding isn’t just about the bound state
Structure·2024
A Single Interfacial Point Mutation Rescues Solution Structure Determination of the Complex of HMG‐D with a DNA Bulge
ChemBioChem·2024· 1 citedOpen Access
Updated protein domain annotation of the PARP protein family sheds new light on biological function
Nucleic Acids Research·2023· 61 citedOpen Access
Updated protein domain annotation of the PARP protein family sheds new light on biological function
HAL (Le Centre pour la Communication Scientifique Directe)·2023Open Access
Trim-Away ubiquitinates and degrades lysine-less and N-terminally acetylated substrates
Nature Communications·2023· 23 citedOpen Access
Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level
Nature Communications·2022· 37 citedOpen Access
Trim-Away degrades lysine-less substrates without requiring ligase autoubiquitination
2022· 3 citedOpen Access
Zinc finger structure determination by NMR: Why zinc fingers can be a handful
Progress in Nuclear Magnetic Resonance Spectroscopy·2022· 35 citedOpen Access
Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level
2022· 2 citedOpen Access
Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level
2022Open Access
Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies
Structure·2021· 23 citedOpen Access
RING domains act as both substrate and enzyme in a catalytic arrangement to drive self-anchored ubiquitination
Nature Communications·2021· 54 citedOpen Access
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition
Nucleic Acids Research·2021· 60 citedOpen Access
La salvació i els jueus: per David Neuhaus
Documents d'Església·2021
Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29
Nature Communications·2020· 34 citedOpen Access
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition
2020· 6 citedOpen Access
Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation
Developmental Cell·2020· 4 citedOpen Access
HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
Nature·2020· 257 citedOpen Access
1H, 13C and 15N chemical shift assignments for VARP 687-747
Biological Magnetic Resonance Bank·2020Open Access
A tri-ionic anchor mechanism drives Ube2N-specific recruitment and K63-chain ubiquitination in TRIM ligases
Nature Communications·2019· 44 citedOpen Access
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Frequent Co-authors

Ji‐Chun Yang(13), John W. R. Schwabe(6), James Keeler(6), Gerhard Wagner(5), Milan Vašák(5), Daniela Rhodes(4), Sebastian Eustermann(4), Jeremias H.R. Kägi(4), Kurt Wüthrich(4), Kiyoshi Nagai(4), Gabriele Varani(4), Murray Stewart(4), Laura E. Easton(3), Ivan Ahel(3), Peter W. A. Howe(3), Lynda Chapman(3), Carlo P. M. van Mierlo(3), Nigel J. Darby(3), Thomas E. Creighton(3), Yukinobu Nakaseko(3)