Patrick J. Bednarski

Universitätsmedizin Greifswald — Germany

Medicine · Health Sciences

38h-index10.8kcitations277works0.92yr avg
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Research Topics

Metal complexes synthesis and properties(73), Crystallization and Solubility Studies(70), X-ray Diffraction in Crystallography(70), Synthesis and biological activity(32), Synthesis and Characterization of Heterocyclic Compounds(30)

Publications275 total

CCDC 2474893: Experimental Crystal Structure Determination
The Cambridge Structural Database·2026Open Access
Bioassay-guided isolation and identification of antiproliferative compounds from Acokanthera schimperi (A.DC.) Schweinf and Gnidia involucrata Steudel ex A. Rich
Fitoterapia·2026Open Access
Cytotoxicity of Atropisomeric [1,1′‐Binaphthalene]‐2,2′‐Diamines (BINAM) and Analogs in Human Cancer Cells: Enantioselectivity, Structure–Activity Relationships, and Mechanism
ChemMedChem·2025Open Access
Crystallographic and Electroanalytical Analyses of Fexinidazole and Its Major Metabolites
ACS Omega·2025Open Access
New K<sub>V</sub>7.2/3 Channel Activators Exhibit Superior Toxicity and Metabolic Profiles to Flupirtine and Demonstrate Promising <i>In Vivo</i> Analgesic Effects
ACS Chemical Neuroscience·2025Open Access
Lead Optimization of Positive Allosteric K<sub>V</sub>7.2/3 Channel Modulators toward Improved Balance of Lipophilicity and Aqueous Solubility
Journal of Medicinal Chemistry·2025· 2 cited
Dose-Dependent Concentration and Penetration Depth of Cisplatin in Human Lung Tissue During Hyperthermic Exposure
Journal of Clinical Medicine·2025· 1 citedOpen Access
Structure‐activity‐relationships of the Stability of Six Pentathiepins Towards Glutathione: Possible Correlations with Biological Activities
ChemMedChem·2024· 1 citedOpen Access
Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety
RSC Medicinal Chemistry·2024· 4 citedOpen Access
Copper(II) Complexes with 1-(Isoquinolin-3-yl)heteroalkyl-2-ones: Synthesis, Structure and Evaluation of Anticancer, Antimicrobial and Antioxidant Potential
International Journal of Molecular Sciences·2023· 7 citedOpen Access
Investigation of TGF‐<i>α</i>‐overexpressing mouse hepatocytes (TAMH) cultured as spheroids for use in hepatotoxicity screening of drug candidates
Journal of Applied Toxicology·2023· 2 citedOpen Access
Dosis-abhängige Cisplatin-Konzentration und -Eindringtiefe in humanes Lungengewebe bei Inkubation in hyperthermer Cisplatin-Lösung
Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie·2023
Liposomal formulation of model pentathiepin improves solubility and stability toward glutathione while preserving anticancer activity
Archiv der Pharmazie·2023· 6 citedOpen Access
Structure‐Activity Relationships of Flupirtine Analogues for Liver Esterase‐Mediated Cleavage of the 4‐Fluorobenzylamine Moiety and Its Possible Relevance to Liver Toxicity
ChemMedChem·2023· 4 citedOpen Access
Supplementary Figure Legend and Methods from &lt;i&gt;Trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;-[Pt&lt;sup&gt;IV&lt;/sup&gt;(N&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;(OH)&lt;sub&gt;2&lt;/sub&gt;(py)(NH&lt;sub&gt;3&lt;/sub&gt;)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
2023Open Access
Supplementary Figure Legend and Methods from &lt;i&gt;Trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;-[Pt&lt;sup&gt;IV&lt;/sup&gt;(N&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;(OH)&lt;sub&gt;2&lt;/sub&gt;(py)(NH&lt;sub&gt;3&lt;/sub&gt;)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
2023Open Access
Supplementary Figure 2 from &lt;i&gt;Trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;-[Pt&lt;sup&gt;IV&lt;/sup&gt;(N&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;(OH)&lt;sub&gt;2&lt;/sub&gt;(py)(NH&lt;sub&gt;3&lt;/sub&gt;)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
2023Open Access
Supplementary Figure 3 from &lt;i&gt;Trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;-[Pt&lt;sup&gt;IV&lt;/sup&gt;(N&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;(OH)&lt;sub&gt;2&lt;/sub&gt;(py)(NH&lt;sub&gt;3&lt;/sub&gt;)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
2023Open Access
Supplementary Figure 6 from &lt;i&gt;Trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;-[Pt&lt;sup&gt;IV&lt;/sup&gt;(N&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;(OH)&lt;sub&gt;2&lt;/sub&gt;(py)(NH&lt;sub&gt;3&lt;/sub&gt;)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
2023Open Access
Data from &lt;i&gt;Trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;,&lt;i&gt;trans&lt;/i&gt;-[Pt&lt;sup&gt;IV&lt;/sup&gt;(N&lt;sub&gt;3&lt;/sub&gt;)&lt;sub&gt;2&lt;/sub&gt;(OH)&lt;sub&gt;2&lt;/sub&gt;(py)(NH&lt;sub&gt;3&lt;/sub&gt;)]: A Light-Activated Antitumor Platinum Complex That Kills Human Cancer Cells by an Apoptosis-Independent Mechanism
2023Open Access
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Frequent Co-authors

Renate Grünert(14), Peter J. Sadler(7), Franciszek Sączewski(6), Aron F. Westendorf(5), Nicole A. Kratochwil(4), Ramzi A. Mothana(3), Luca Salassa(3), Przemysław Reszka(3), Fiona Mackay(2), Ulrike Lindequist(2), Renate Gruenert(2), Christian G. Hartinger(2), Michael A. Jakupec(2), Bernhard K. Keppler(2), Piotr Szumlas(2), Magdalena Buczkowska(2), М. Gdaniec(2), Robert Banaschik(2), Juergen F. Kolb(2), Dianne M. Fisher(2)