Zbigniew M. Darżynkiewicz

Łukasiewicz Research Network – PORT Polish Center for Technology Development — Poland

Biochemistry, Genetics and Molecular Biology · Life Sciences

9h-index419citations21works0.52yr avg
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Research Topics

RNA and protein synthesis mechanisms(11), RNA Research and Splicing(8), Quantum Dots Synthesis And Properties(3), RNA Interference and Gene Delivery(3), RNA modifications and cancer(3)

Publications21 total

Binding of Cytochrome c to CdTe Colloidal Quantum Dots─Investigation of Stoichiometry and Thermodynamics of the Nanohybrid Creation Process
ACS Omega·2025· 1 citedOpen Access
Analysis of ligand binding mechanism by dimeric receptors using stopped-flow fluorimetry—application to the human decapping scavenger enzyme
European Biophysics Journal·2025
Development of bis-ANS-based modified fluorescence titration assay for IFIT/RNA studies
Biochemical and Biophysical Research Communications·2020· 3 citedOpen Access
Kinetic analysis of IFIT1 and IFIT5 interactions with different native and engineered RNAs and its consequences for designing mRNA-based therapeutics
RNA·2019· 19 citedOpen Access
Direct Inhibition of MmpL3 by Novel Antitubercular Compounds
ACS Infectious Diseases·2019· 96 citedOpen Access
Identification of Binding Sites for Efflux Pump Inhibitors of the AcrAB-TolC Component AcrA
Biophysical Journal·2019· 38 citedOpen Access
Quantum dots use both LUMO and surface trap electrons in photoreduction process
Journal of Luminescence·2016· 12 cited
Insight from photoluminescence into mechanism of heme and iron-sulfur cluster photoreduction mediated by CdTe quantum dots
2016
Effect of different N7 substitution of dinucleotide cap analogs on the hydrolytic susceptibility towards scavenger decapping enzymes (DcpS)
Biochemical and Biophysical Research Communications·2015· 6 cited
Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes
Nucleic Acids Research·2014· 54 citedOpen Access
Biofizyczne podstawy molekularnego mechanizmu wiązania 5' końca kwasu rybonukleinowego przez białko degradujące DcpS
2014
Synthesis and properties of mRNA cap analogs containing imidodiphosphate moiety—fairly mimicking natural cap structure, yet resistant to enzymatic hydrolysis
Bioorganic & Medicinal Chemistry·2012· 57 citedOpen Access
Synthetic dinucleotide mRNA cap analogs with tetraphosphate 5′,5′ bridge containing methylenebis(phosphonate) modification
Organic & Biomolecular Chemistry·2009· 54 cited
The first examples of mRNA cap analogs bearing boranophosphate modification
Nucleic Acids Symposium Series·2008· 7 citedOpen Access
Synthesis and properties of boranophosphate mRNA cap analogues
2008· 2 cited
Affinity of Dinucleotide Cap Analogues for Human Decapping Scavenger (hDcpS)
Nucleosides Nucleotides & Nucleic Acids·2007· 9 cited
Interaction of human decapping scavenger with 5′ mRNA cap analogues: structural requirements for catalytic activity
Journal of Physics Condensed Matter·2007· 11 cited
Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme
Bioorganic & Medicinal Chemistry·2006· 50 cited
Dinucleotide 5' mRNA cap analogues with modified triphosphate bridge: useful tools to study decapping and translation
Acta Biochimica Polonica·2006Open Access
Synthesis and biochemical properties of the novel, enzymatically stable mRNA cap analogues with versatile potential applications
2005
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Frequent Co-authors

Edward Darżynkiewicz(13), Jacek Jemielity(12), Joanna Kowalska(8), Joanna Zuberek(8), Elżbieta Bojarska(7), Janusz Stȩpiński(7), Richard E. Davis(6), Maciej Łukaszewicz(5), Robert E. Rhoads(4), Marcin Kałek(4), Ryszard Stolarski(4), Joanna Grzyb(3), Magdalena Lewdorowicz(3), Helen I. Zgurskaya(2), Anna M. Rydzik(2), Anna Dobieżyńska(2), Joanna Miszkiewicz(2), Michał Tyras(2), Joanna Trylska(2), Renata Grzela(2)