Filip Van Petegem

University of British Columbia — Canada

Biochemistry, Genetics and Molecular Biology · Life Sciences

45h-index6.1kcitations307works1.42yr avg
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Research Topics

Ion channel regulation and function(156), Cardiac electrophysiology and arrhythmias(113), Cardiomyopathy and Myosin Studies(28), Neuroscience and Neuropharmacology Research(20), Receptor Mechanisms and Signaling(15)

Publications307 total

An inter-subunit path is required for entropically-driven and negatively cooperative binding of cyclic nucleotides in the HCN2 channel
Communications Biology·2026Open Access
BPS2026 – Elucidation of the membrane binding properties of Junctophilin
Biophysical Journal·2026
BPS2026 – Cav1.2 EF-hand and IQ domain variants of uncertain significance (VUS) affect Ca2+ current and Ca2+ homeostasis differently
Biophysical Journal·2026
BPS2026 - Cryo-EM study of the malignant hyperthermia-causing T4826I mutant of ryanodine receptor 1 and its regulation by pharmacological inhibitors
Biophysical Journal·2026
BPS2026 - Structural basis for the modulation of ryanodine receptors by calcins
Biophysical Journal·2026
Identification of novel potentially causative RYR1 variants in individuals with malignant hyperthermia susceptibility
Neuromuscular Disorders·2025Open Access
Cryo-electron microscopy reveals sequential binding and activation of Ryanodine Receptors by statin triplets
Nature Communications·2025· 1 citedOpen Access
Crystal structures of Ryanodine Receptor reveal dantrolene and azumolene interactions guiding inhibitor development
Nature Communications·2025Open Access
Abstract 4343799: Genetically informed drug targeting of ryanodine receptor type 2 identifies new precision therapeutic candidates for catecholaminergic polymorphic ventricular tachycardia
Circulation·2025
Direct Therapeutic Modulation of RYR2 Activity by CMYA5
Circulation·2025Open Access
Phosphorylation of RYR1 at Ser <sup>2902</sup> decreases Ca <sup>2+</sup> leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke
Science Signaling·2025
Cathepsin K as a Key Protease in Processing of SARS-CoV-2 Spike Activation Sites and a Target of Dual-Inhibition
2025Open Access
A physiologically-relevant intermediate state structure of a voltage-gated potassium channel
Nature Communications·2025· 1 citedOpen Access
Novel Peptide Therapeutics Targeting the L-Type Calcium Channel Prevent Hypertrophic Cardiomyopathy by Decreasing Mitochondrial Energetics
JACC Basic to Translational Science·2025Open Access
CACNA1C c.4558C&gt;A (p.Leu1520Ile) Variant of Uncertain Significance and Associated With Long QT Syndrome 8 is a Cav1.2 Gain-of-Function Mutation
Heart Lung and Circulation·2025Open Access
Abstract Fri084: Electrophysiological characterization of L1521I-Ca <sub>v</sub> 1.2 mutation reported in a cardiology patient provides insight into channel structure
Circulation Research·2025
Natural Peptide Modulators of Ryanodine Receptors Produced by a High-Throughput Expression System
Journal of Molecular and Cellular Cardiology Plus·2025Open Access
A robust expression system reveals distinct gating mechanisms and calmodulin regulation of Na <sub>V</sub> 1.9 channels
Science Advances·2025Open Access
BPS2025 - Electrophysiological and structural characterization of the binding of the cardiac ion channel blocker UCL2077 to KCNQ1 channels
Biophysical Journal·2025
BPS2025 - Cryo-EM reveals binding and activation of the ryanodine receptor by multiple statin molecules
Biophysical Journal·2025
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Frequent Co-authors

Ching‐Chieh Tung(8), Zhiguang Yuchi(7), Daniel L. Minor(6), Paolo A. Lobo(6), Lynn Kimlicka(6), Kelvin Lau(6), Omid Haji‐Ghassemi(4), Christopher A. Ahern(3), Thomas M. Roston(3), Shubhayan Sanatani(3), Harry Brumer(3), Kimberly A. Clark(2), Franck C. Chatelain(2), Kellie A. Woll(2), Jozef Van Beeumen(2), Maen F. Sarhan(2), Susan P. Etheridge(2), James E. Potts(2), Kathleen R. Maginot(2), Martin J. LaPage(2)