Nicholas J. Edmunds

AstraZeneca (United Kingdom) — United Kingdom

Medicine · Health Sciences

12h-index658citations22works0.02yr avg
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Research Topics

Nitric Oxide and Endothelin Effects(5), High Altitude and Hypoxia(4), Sexual function and dysfunction studies(3), Receptor Mechanisms and Signaling(3), Crystallization and Solubility Studies(3)

Publications22 total

Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein
Molecular Therapy — Nucleic Acids·2021· 84 citedOpen Access
Extracellular vesicles induce minimal hepatotoxicity and immunogenicity
Nanoscale·2019· 186 cited
2′-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells
Toxicological Sciences·2018· 6 citedOpen Access
Predicting Drug Safety and Communicating Risk: Benefits of a Bayesian Approach
Toxicological Sciences·2017· 28 citedOpen Access
Predicting drug safety and communicating risk: benefits of a Bayesian approach
2017· 3 citedOpen Access
Respiratory measurements in rats as indicator of adverse respiratory reactions to inhaled drugs
Journal of Pharmacological and Toxicological Methods·2016
Exenatide exerts a PKA-dependent positive inotropic effect in human atrial myocardium
Journal of Molecular and Cellular Cardiology·2015· 58 cited
CCDC 751559: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
CCDC 751560: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
CCDC 751558: Experimental Crystal Structure Determination
The Cambridge Structural Database·2011Open Access
Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: Design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence
Bioorganic & Medicinal Chemistry Letters·2010· 12 citedOpen Access
Cardiovascular safety assessments in the conscious telemetered dog: Utilisation of super-intervals to enhance statistical power
Journal of Pharmacological and Toxicological Methods·2010· 51 cited
Reflex penile erection in anesthetized mice: An exploratory study
Neuroscience·2008· 15 cited
Potentiation of reflex erectile responses in the anaesthetized rat by the selective melanocortin receptor 4 agonist MB243
British Journal of Urology·2008· 5 cited
Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation?<i>in vivo</i> and <i>in vitro</i> studies
The Journal of Physiology·2003· 42 citedOpen Access
The Roles of Nitric Oxide in Dilating Proximal and Terminal Arterioles of Skeletal Muscle during Systemic Hypoxia
Journal of Vascular Research·2003· 22 cited
Membership of the ESM
Journal of Vascular Research·2003Open Access
Oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: role of adenosine
The Journal of Physiology·2001· 28 citedOpen Access
Vasodilatation, oxygen delivery and oxygen consumption in rat hindlimb during systemic hypoxia: roles of nitric oxide
The Journal of Physiology·2001· 41 citedOpen Access
Effects of tumour necrosis factor‐α on left ventricular function in the rat isolated perfused heart: possible mechanisms for a decline in cardiac function
British Journal of Pharmacology·1999· 51 citedOpen Access
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Frequent Co-authors

Janice M. Marshall(5), Mark I. Lansdell(3), David Hepworth(3), Andrew Calabrese(3), A.D. Brown(3), J. Blagg(3), Denise J. Burring(3), David Fradet(3), T.B. Brown(3), F. Quinton(3), N. B. Mistry(3), Kan Tang(3), P Stacey(3), C. Adams(3), S. Gaboardi(3), S. Neal-Morgan(3), C. Wayman(3), J. Phipps(3), Michael B. Lewis(3), Hugh Verrier(3)