Jeffery A. Porter

Novartis (United States) — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

35h-index17.5kcitations42works0.02yr avg
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Research Topics

Hedgehog Signaling Pathway Studies(16), Developmental Biology and Gene Regulation(10), Cancer-related gene regulation(7), Epigenetics and DNA Methylation(6), Wnt/β-catenin signaling in development and cancer(5)

Publications42 total

Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy
Cell chemical biology·2023· 138 citedOpen Access
Systematic Chemogenetic Library Assembly
Cell chemical biology·2020· 55 citedOpen Access
Systematic Chemogenetic Library Assembly
2020· 9 citedOpen Access
Discovery of a ZIP7 inhibitor from a Notch pathway screen
Nature Chemical Biology·2018· 65 citedOpen Access
Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening
Cell·2017· 687 citedOpen Access
Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
eLife·2016· 152 citedOpen Access
Author response: Functional CRISPR screening identifies the ufmylation pathway as a regulator of SQSTM1/p62
2016· 4 citedOpen Access
Erratum: Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
Nature Chemical Biology·2016· 4 citedOpen Access
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5
Science·2016· 539 cited
Erratum: Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice
Nature Chemical Biology·2015· 1 citedOpen Access
SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice
Nature Chemical Biology·2015· 422 cited
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
Nature Cell Biology·2014· 719 cited
Functional epigenetics approach identifies BRM/SMARCA2 as a critical synthetic lethal target in BRG1-deficient cancers
Proceedings of the National Academy of Sciences·2014· 405 citedOpen Access
Inactivating mutations of <i>RNF43</i> confer Wnt dependency in pancreatic ductal adenocarcinoma
Proceedings of the National Academy of Sciences·2013· 412 citedOpen Access
NON-TRANSFERRIN-BOUND IRON (NTBI) AND APOTRANSFERRIN STIMULATE THE EXPRESSION OF L-TYPE VOLTAGE-GATED CALCIUM CHANNELS OF CARDIOMYOCYTES
UCL Discovery (University College London)·2013
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner
Nature·2012· 957 cited
RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
Nature Cell Biology·2011· 428 cited
Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies
Proceedings of the National Academy of Sciences·2010· 153 citedOpen Access
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling
Nature·2009· 2.1k cited
Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling
Nature Medicine·2005· 301 cited
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Frequent Co-authors

John A. Tallarico(12), Philip A. Beachy(12), Craig Mickanin(8), Vic E. Myer(8), Shanming Liu(6), Martin Beibel(6), Guglielmo Roma(6), Gregory A. Michaud(5), Olga Charlat(5), Marc Hild(5), Xiaoying Shi(5), Peter M. Finan(5), Feng Cong(5), Keith E. Young(5), Jason R. Thomas(5), Gregory R. Hoffman(5), Atwood K. Cheung(4), Frank Stegmeier(4), Markus Schirle(4), David T. Chang(4)