Thomas Kjeldsen

Novo Nordisk (Denmark) — Denmark

Medicine · Health Sciences

33h-index3.8kcitations76works3.32yr avg
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Research Topics

Pancreatic function and diabetes(26), Metabolism, Diabetes, and Cancer(15), Diabetes Management and Research(14), Glycosylation and Glycoproteins Research(13), Growth Hormone and Insulin-like Growth Factors(13)

Publications76 total

Application of structural insights in the molecular engineering of insulin for recombinant expression in yeast
Acta Crystallographica Section A Foundations and Advances·2024
Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec
Nature Communications·2024· 13 citedOpen Access
Predicting human half-life for insulin analogs: An inter-drug approach
European Journal of Pharmaceutics and Biopharmaceutics·2024
Predicting Human Half-Life for Insulin Analogs: An Inter-Drug Approach
SSRN Electronic Journal·2024Open Access
Molecular engineering of insulin for recombinant expression in yeast
Trends in biotechnology·2023· 25 citedOpen Access
815-P: Enhanced Disulphide Bond Stability Contributes to the Once Weekly PD Profile of Insulin Icodec
Diabetes·2023
Derivatization with fatty acids in peptide and protein drug discovery
Nature Reviews Drug Discovery·2022· 108 cited
Molecular and Biological Properties of Insulin Icodec, a New Insulin Analog Designed to Give a Long Half-Life Suitable for Once-Weekly Dosing
Diabetologie und Stoffwechsel·2022· 2 cited
Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates
Journal of Medicinal Chemistry·2022· 5 cited
A Hundred Years of Insulin Innovation: When Science Meets Technology
Diabetes·2021· 4 citedOpen Access
Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing
BMJ Open Diabetes Research & Care·2021· 131 citedOpen Access
Commemorating insulin's centennial: engineering insulin pharmacology towards physiology
Trends in Pharmacological Sciences·2021· 45 citedOpen Access
Cell free protein synthesis versus yeast expression – A comparison using insulin as a model protein
Protein Expression and Purification·2021· 12 citedOpen Access
Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans
Journal of Medicinal Chemistry·2021· 115 cited
Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320
Journal of Medicinal Chemistry·2020· 36 cited
Author Correction: Molecular engineering of safe and efficacious oral basal insulin
Nature Communications·2020· 1 citedOpen Access
Dually Reactive Long Recombinant Linkers for Bioconjugations as an Alternative to PEG
ACS Omega·2020· 4 citedOpen Access
Molecular engineering of safe and efficacious oral basal insulin
Nature Communications·2020· 56 citedOpen Access
236-OR: Molecular and Biological Properties of Insulin Icodec, a New Insulin Analog Designed to Give a Long Half-Life Suitable for Once-Weekly Dosing
Diabetes·2020· 23 cited
Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs
Diabetes Obesity and Metabolism·2019· 11 citedOpen Access
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Frequent Co-authors

Asser S. Andersen(14), Erica Nishimura(14), František Hubálek(11), Morten Hach(10), Carsten E. Stidsen(9), Peter Madsen(8), A. Pettersson(8), Finn C. Wiberg(7), Tine Glendorf(7), Svend Ludvigsen(6), Lone Pridal(5), Anders R. Sørensen(5), Eva Johansson(5), Svend Havelund(4), Jesper Rasmussen(4), L. Schäffer(4), Per Balschmidt(4), Thomas Åskov Pedersen(4), Peter Kurtzhals(4), Dorte B. Steensgaard(4)