Daniel O’Reilly

University of Massachusetts Chan Medical School — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index465citations45works4.62yr avg
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Research Topics

RNA Interference and Gene Delivery(11), CRISPR and Genetic Engineering(11), Genetic Neurodegenerative Diseases(11), DNA and Nucleic Acid Chemistry(10), Advanced biosensing and bioanalysis techniques(9)

Publications45 total

Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
Nature Communications·2025Open Access
0940 Assessing the preclinical potential of the selective p38δ silencing in human skin organoids (HSO) and ex vivo human skin explant model of atopic dermatitis
Journal of Investigative Dermatology·2025
Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington’s disease pathogenesis in mice
2025· 3 citedOpen Access
Systematic analysis of siRNA and mRNA features impacting fully chemically modified siRNA efficacy
Nucleic Acids Research·2025· 11 citedOpen Access
Lowering the <i>HTT1a</i> transcript as an effective therapy for Huntington’s disease
2025· 2 citedOpen Access
Systematic Evaluation of Position-Specific Tolerability of Seven Backbone and Ribose Modifications in Fully Chemically Stabilized siRNAs
Nucleic Acid Therapeutics·2025· 2 cited
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model
2025Open Access
Single-dose administration of therapeutic divalent siRNA targeting MECP2 prevents lethality for one year in an MECP2 duplication mouse model
2025· 5 citedOpen Access
Mutant Huntingtin exon1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MSH3 silencing, and aggregation
2025Open Access
Mutant huntingtin exon 1 protein detected in mouse brain with neoepitope antibody: effects of CAG repeat expansion, MutS Homolog 3 silencing and aggregation
Brain Communications·2025· 2 citedOpen Access
Chemical engineering of CRISPR–Cas systems for therapeutic application
Nature Reviews Drug Discovery·2024· 25 cited
Suppression of Huntington’s Disease Somatic Instability by Transcriptional Repression and Direct CAG Repeat Binding
2024· 6 citedOpen Access
Red Blood Cell Transfusion in European Neonatal Intensive Care Units, 2022 to 2023
JAMA Network Open·2024· 15 citedOpen Access
A011 Blocking Huntingtin’s transcription protects against somatic instability
2024Open Access
Near Sequence Homology Does Not Guarantee siRNA Cross-Species Efficacy
Nucleic Acid Therapeutics·2024· 3 citedOpen Access
A Guide to Chemical Considerations for the Pre-Clinical Development of Oligonucleotides
Nucleic Acid Therapeutics·2024· 2 citedOpen Access
mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs <i>In Vivo</i>
Nucleic Acid Therapeutics·2024· 4 citedOpen Access
mRNA nuclear clustering leads to a difference in mutant huntingtin mRNA and protein silencing by siRNAs <i>in vivo</i>
2024· 2 citedOpen Access
Challenges of Assessing Exon 53 Skipping of the Human <i>DMD</i> Transcript with Locked Nucleic Acid-Modified Antisense Oligonucleotides in a Mouse Model for Duchenne Muscular Dystrophy
Nucleic Acid Therapeutics·2023· 10 citedOpen Access
Di-valent siRNA-mediated silencing of MSH3 blocks somatic repeat expansion in mouse models of Huntington’s disease
Molecular Therapy·2023· 7 citedOpen Access
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Frequent Co-authors

Masad J. Damha(18), Anastasia Khvorova(15), Dimas Echeverria(12), Ashley Summers(11), Jillian Belgrad(9), Vignesh Hariharan(9), Neil Aronin(9), Ellen Sapp(8), Chantal Ferguson(7), Nicholas McHugh(7), Cassandra McHugh(6), Ella Mathews(6), Zachary Kennedy(6), Kathryn Monopoli(6), Marian DiFiglia(6), Ken Yamada(6), Keith T. Gagnon(5), Socheata Ly(5), Raymond Furgal(5), David Cooper(5)