Karla Helvie

Dana-Farber Cancer Institute — United States

Medicine · Health Sciences

15h-index3.4kcitations113works7.02yr avg
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Research Topics

Advanced Breast Cancer Therapies(56), Cancer Genomics and Diagnostics(51), Cancer Treatment and Pharmacology(41), Breast Cancer Treatment Studies(35), Pancreatic and Hepatic Oncology Research(17)

Publications112 total

Single-cell epigenetic profiling reveals a tumor-intrinsic interferon response program in ccRCC tied to poor prognosis and <i>BAP1</i> loss
Science Advances·2026Open Access
Abstract PS3-12-15: Mapping the imprint of taxane chemotherapy on the metastatic microenvironment in HR+ breast cancer with single cell and spatial profiling
Clinical Cancer Research·2026
Understanding tumor-immune-stromal dynamics driving response and resistance to immune checkpoint blockade in melanoma 4125
The Journal of Immunology·2025Open Access
A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma
Nature Cancer·2025· 2 citedOpen Access
SlideCNA: spatial copy number alteration detection from Slide-seq-like spatial transcriptomics data
Genome biology·2025Open Access
Abstract 6256: Dissecting tumor-intrinsic programs and immune dynamics driving response to immunotherapy in metastatic melanoma through non-negative matrix factorization decomposition
Cancer Research·2025
Abstract 6605: Spatially-resolved single-cell transcriptome landscape of response and resistance to CDK4/6 inhibitors in patients with hormone receptor-positive metastatic breast cancer
Cancer Research·2025
Abstract 4536: Dissecting tumor-immune microenvironment in response and resistance to immune checkpoint blockade in metastatic melanoma
Cancer Research·2025
Author Correction: A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Nature Medicine·2025Open Access
Single-cell epigenetic profiling reveals an interferon response-high program associated with <i>BAP1</i> deficiency in kidney cancer
2024· 4 citedOpen Access
A multi-modal single-cell and spatial expression map of metastatic breast cancer biopsies across clinicopathological features
Nature Medicine·2024· 50 citedOpen Access
Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine
UNC Libraries·2024Open Access
Abstract GS03-09: Characterization and proposed therapeutic exploitation of fusion RNAs in metastatic breast cancers
Cancer Research·2024· 4 cited
Abstract 2486: Dissecting tumor-immune interaction in response and resistance to immune checkpoint blockade in metastatic melanoma
Cancer Research·2024
Exemestane plus everolimus and palbociclib in metastatic breast cancer: clinical response and genomic/transcriptomic determinants of resistance in a phase I/II trial
Nature Communications·2024· 24 citedOpen Access
A spatial cell atlas of neuroblastoma reveals developmental, epigenetic and spatial axis of tumor heterogeneity
2024· 28 citedOpen Access
Supplemental Table 6 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer
2023Open Access
Supplementary Figures from Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine
2023Open Access
Supplemental Table 1 from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer
2023Open Access
Data from The Genomic Landscape of Intrinsic and Acquired Resistance to Cyclin-Dependent Kinase 4/6 Inhibitors in Patients with Hormone Receptor–Positive Metastatic Breast Cancer
2023· 1 citedOpen Access
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Frequent Co-authors

Nikhil Wagle(42), Nancy U. Lin(27), Ofir Cohen(26), Eric P. Winer(26), Levi A. Garraway(25), Adrienne G. Waks(22), Sara M. Tolaney(22), Maxwell R. Lloyd(20), Lori Marini(18), Seth A. Wander(18), Jorge E. Buendia-Buendia(17), Utthara Nayar(16), Melissa E. Hughes(16), Dewey Kim(15), Nelly Oliver(14), Pingping Mao(14), Bruce E. Johnson(14), Gad Getz(12), Gabriela N. Johnson(12), Flora Luo(12)