L. Fiume

University of Bologna — Italy

Biochemistry, Genetics and Molecular Biology · Life Sciences

36h-index4.2kcitations140works0.02yr avg
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Research Topics

Glycosylation and Glycoproteins Research(23), Silymarin and Mushroom Poisoning(22), Cancer, Hypoxia, and Metabolism(17), Hepatitis B Virus Studies(14), Hepatocellular Carcinoma Treatment and Prognosis(12)

Publications140 total

The inhibition of lactate dehydrogenase A hinders the transcription of histone 2B gene independently from the block of aerobic glycolysis
Biochemical and Biophysical Research Communications·2017· 10 cited
Lactate Dehydrogenase Inhibition: Exploring Possible Applications Beyond Cancer Treatment
Future Medicinal Chemistry·2016· 34 cited
Lactate dehydrogenase inhibitors sensitize lymphoma cells to cisplatin without enhancing the drug effects on immortalized normal lymphocytes
European Journal of Pharmaceutical Sciences·2015· 44 citedOpen Access
Comment on: Targeting homologous recombination-mediated DNA repair in cancer
Expert Opinion on Therapeutic Targets·2014· 2 cited
Albumin–drug conjugates in the treatment of hepatic disorders
Expert Opinion on Drug Delivery·2014· 9 cited
Inhibition of Lactate Dehydrogenase Activity as an Approach to Cancer Therapy
Future Medicinal Chemistry·2014· 97 cited
Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells
Biochemical and Biophysical Research Communications·2012· 32 cited
Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways
European Journal of Pharmaceutical Sciences·2012· 149 cited
Galloflavin (CAS 568‐80‐9): A Novel Inhibitor of Lactate Dehydrogenase
ChemMedChem·2011· 190 citedOpen Access
Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells
European Journal of Pharmacology·2011· 36 citedOpen Access
Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors
Pharmacological Research·2010· 41 cited
Lactosaminated human albumin, a hepatotropic carrier of drugs
European Journal of Pharmaceutical Sciences·2010· 28 cited
Impairment of Aerobic Glycolysis by Inhibitors of Lactic Dehydrogenase Hinders the Growth of Human Hepatocellular Carcinoma Cell Lines
Pharmacology·2010· 60 cited
Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopy
European Journal of Pharmaceutical Sciences·2009· 12 cited
The enhancement of interstitial transport of a doxorubicin–lactosaminated albumin conjugate by imatinib: In rat hepatocellular carcinoma it is not preferentially higher than that in liver and bone marrow
European Journal of Pharmaceutics and Biopharmaceutics·2009· 4 cited
Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug
Drug Discovery Today·2008· 21 cited
Binding of the doxorubicin–lactosaminated human albumin conjugate to HCC cells is mediated by the drug moieties
Digestive and Liver Disease·2008· 4 cited
Doxorubicin coupled to lactosaminated albumin: Effect of heterogeneity in drug load on conjugate disposition and hepatocellular carcinoma uptake in rats
European Journal of Pharmaceutical Sciences·2008· 15 cited
Efficacy of doxorubicin coupled to lactosaminated albumin on rat hepatocellular carcinomas evaluated by ultrasound imaging
Digestive and Liver Disease·2007· 28 cited
Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin
European Journal of Pharmaceutical Sciences·2006· 13 cited
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Frequent Co-authors

Giuseppina Di Stefano(22), A Mattioli(16), C. Busi(15), Marcella Manerba(8), Marina Vettraino(7), Felix Kratz(6), Marcella Lanza(5), Pier Giorgio Balboni(4), G. Barbanti‐Brodano(4), Ferruccio Bonino(4), G Verme(4), Marinella Roberti(3), Fiorenzo Stirpe(3), Massimo Derenzini(3), V. Marinozzi(3), G. Spinosa(3), Gabriella Campadelli‐Fiume(3), G.B. Gervasi(3), Pasquale Chieco(3), Heinz Faulstich(2)