Alfred C. Chin

Cornell University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

11h-index422citations29works1.92yr avg
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Research Topics

Cellular Mechanics and Interactions(5), Protein Kinase Regulation and GTPase Signaling(4), Cellular transport and secretion(4), Neuroscience and Neuropharmacology Research(3), Cardiomyopathy and Myosin Studies(3)

Publications29 total

Synthetic nanomachine reveals mechanics of a non‐muscle actinopathy mutation in γ‐actin
The Journal of Physiology·2026Open Access
BPS2026 – Force-modulated structural landscape of the catch bonding actin crosslinker α-actinin-4
Biophysical Journal·2026
Cytoskeleton Spotlight: Alfred C. Chin
Cytoskeleton·2025Open Access
IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence
2025Open Access
IP6K1 Rewires LKB1 Signaling to Mediate Hyperglycemic Endothelial Senescence
Diabetes·2025· 1 cited
IP6K1 rewires LKB1 signaling to mediate hyperglycemic endothelial senescence
2025Open Access
Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I
Metabolism·2024· 4 citedOpen Access
Deleting IP6K1 stabilizes neuronal sodium–potassium pumps and suppresses excitability
Molecular Brain·2024· 2 citedOpen Access
Depleting inositol pyrophosphate 5-InsP7 protected the heart against ischaemia–reperfusion injury by elevating plasma adiponectin
Cardiovascular Research·2024· 10 citedOpen Access
Methotrexate for gestational choriocarcinoma: a paradigm shift in oncology
Nature Reviews Endocrinology·2023· 4 cited
Itraconazole inhibits endothelial cell migration by disrupting inositol pyrophosphate-dependent focal adhesion dynamics and cytoskeletal remodeling
Biomedicine & Pharmacotherapy·2023· 15 citedOpen Access
Myosin modulators move forward with FDA approval of mavacamten
Nature Cardiovascular Research·2022· 7 cited
Structural biology and thermodynamics of GluD receptors
Neuropharmacology·2021· 3 cited
Blockchain Biology
Frontiers in Blockchain·2020· 5 citedOpen Access
Self-reported health without clinically measurable benefits among adult users of multivitamin and multimineral supplements: a cross-sectional study
BMJ Open·2020· 14 citedOpen Access
The inositol pyrophosphate 5-InsP <sub>7</sub> drives sodium-potassium pump degradation by relieving an autoinhibitory domain of PI3K p85α
Science Advances·2020· 27 citedOpen Access
D-Serine Potently Drives Ligand-Binding Domain Closure in the Ionotropic Glutamate Receptor GluD2
Structure·2020· 18 citedOpen Access
Blockchain Biology
2020· 1 citedOpen Access
Theoretical realities
Nature Reviews Chemistry·2020
PERK-STING Signaling Drives Neuroinflammation in Traumatic Brain Injury
Journal of Neuroscience·2020· 17 citedOpen Access
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Frequent Co-authors

Chenglai Fu(12), Dorothea Fiedler(7), Tomás Rojas(5), Solomon H. Snyder(5), Tim Aguirre(5), Weiwei Cheng(4), Andrew M. Riley(4), David Furkert(4), Barry V. L. Potter(4), Zhe Gao(3), Xiaoqi Liu(3), Albert Y. Lau(3), Ji Qi(3), Yuanyuan Chen(3), Megan L. Shipton(3), Changchang Xing(3), Linhui Shi(3), Limei Zhu(3), Alex F. Chen(3), Jing Xu(2)