Karen Harrington‐Brock

Environmental Protection Agency — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.0kcitations23works0.02yr avg
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Research Topics

Carcinogens and Genotoxicity Assessment(14), DNA Repair Mechanisms(6), Arsenic contamination and mitigation(3), Acute Lymphoblastic Leukemia research(3), Animal testing and alternatives(3)

Publications23 total

Bromate induces loss of heterozygosity in the Thymidine kinase gene of L5178Y/Tk+/−-3.7.2C mouse lymphoma cells
Mutation Research/Genetic Toxicology and Environmental Mutagenesis·2003· 36 cited
Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: Induction of chromosomal mutations but not gene mutations
Environmental and Molecular Mutagenesis·2003· 200 cited
Mouse lymphoma thymidine kinase gene mutation assay: Follow‐up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000
Environmental and Molecular Mutagenesis·2002· 65 citedOpen Access
Mutagenicity of trichloroethylene and its metabolites: implications for the risk assessment of trichloroethylene.
Environmental Health Perspectives·2000· 65 citedOpen Access
Mouse lymphoma thymidine kinase locus gene mutation assay: International Workshop on Genotoxicity Test Procedures Workgroup report
Environmental and Molecular Mutagenesis·2000· 48 cited
Effects of arsenic exposure on the frequency of HPRT-mutant lymphocytes in a population of copper roasters in Antofagasta, Chile: a pilot study
Mutation research. Fundamental and molecular mechanisms of mutagenesis·1999· 14 cited
Mutagenicity of three disinfection by-products: di- and trichloroacetic acid and chloral hydrate in L5178Y/TK+/− −3.7.2C mouse lymphoma cells
Mutation Research/Genetic Toxicology and Environmental Mutagenesis·1998· 55 cited
Human in vivo somatic mutation measured at two loci: individuals with stably elevated background erythrocyte glycophorin A (gpa) variant frequencies exhibit normal T-lymphocyte hprt mutant frequencies
Mutation research. Fundamental and molecular mechanisms of mutagenesis·1998· 34 cited
Identification and chromosomal assignment of two heterozygous mutations in the <i>Trp53</i> gene in L5178Y\<i>Tk</i> <sup>+\−</sup>-3.7.2C mouse lymphoma cells
Mutagenesis·1998· 41 cited
Relative genotoxic potency of arsenic and its methylated metabolites
Mutation Research/Reviews in Mutation Research·1997· 162 cited
Biological effects of arsenic exposure—integration of in vitro genotoxicity data with human biomarker data
1997
Deletion mutations in the <i>hprt</i> gene of T-lymphocytes as a biomarker for genomic rearrangements important in human cancers
Carcinogenesis·1994· 20 cited
Quantification and molecular characterization of hprt mutants of human T-lymphocytes.
Environmental Health Perspectives·1993· 8 citedOpen Access
Quantification and Molecular Characterization of hprt Mutants of Human T-Lymphocytes
Environmental Health Perspectives·1993· 1 citedOpen Access
Large deletions are tolerated at the hprt locus of in vivo derived human T-lymphocytes
Mutation Research Letters·1992· 46 cited
V(D)J recombinase-mediated deletion of the hprt gene in T-lymphocytes from adult humans
Mutation Research Letters·1992· 70 cited
Genotoxicity of 2-amino-6-N-hydroxyadenine (AHA) to mouse lymphoma and CHO cells
Mutation Research/Environmental Mutagenesis and Related Subjects·1991· 11 cited
Comparison of mutagenicity results for nine compounds evaluated at the <i>hgprt</i> locus in the standard and suspension CHO assays
Mutagenesis·1991· 22 cited
Analysis of the genotoxicity of anthraquinone dyes in the mouse lymphoma assay
Mutagenesis·1991· 16 cited
Genotoxicity in mouse lymphoma cells of chemicals capable of Michael addition
Mutagenesis·1991· 57 cited
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Frequent Co-authors

Martha M. Moore(21), Carolyn L. Doerr(8), James C. Fuscoe(7), Lisa J. Zimmerman(5), Deborah D. Collard(3), Lisa Parker(3), Andrew D. Kligerman(2), James W. Allen(2), David M. DeMarini(2), Lisa Burnette(2), John P. O’Neill(2), Masamitsu Honma(2), Julie Clements(2), Takumi Awogi(2), George Bölcsföldi(2), B. Bhaskar Gollapudi(2), Wolfgang Muster(2), B. Myhr(2), Michael R. O’Donovan(2), Marie‐Claude Ouldelhkim(2)