Hien Zhao

The University of Texas at Dallas — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

16h-index1.6kcitations50works2.82yr avg
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Research Topics

RNA Research and Splicing(11), RNA regulation and disease(11), Parkinson's Disease Mechanisms and Treatments(9), Prion Diseases and Protein Misfolding(8), Neurogenetic and Muscular Disorders Research(6)

Publications50 total

Progressive neurodegeneration in human dorsal root ganglion from diabetes to painful neuropathy
2026Open Access
Atrophin-1 antisense oligonucleotide provides robust protection from pathology in a fully humanized DRPLA model
Molecular Therapy — Nucleic Acids·2025Open Access
RAB5 Hyperactivation Induces APP‐Driven Endolysosomal and Autophagic Dysfunction in Down Syndrome: Reversal by Antisense Oligonucleotides Targeting <i>App</i> and <i>Rab5</i>
Alzheimer s & Dementia·2025Open Access
Cell Type Distribution of Intrathecal Antisense Oligonucleotide Activity in Deep Brain Regions of Non-Human Primates
Nucleic Acid Therapeutics·2025· 1 citedOpen Access
Peripherally administered androgen receptor–targeted antisense oligonucleotide rescues spinal pathology in a murine SBMA model
Journal of Clinical Investigation·2025· 1 citedOpen Access
SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides
Neurobiology of Disease·2025· 4 citedOpen Access
Analgesic actions of Intrathecal NaV 1.7 antisense in rats: loss of antagonist channel binding, message depletion, and neuraxial distribution of oligonucleotide
2025Open Access
Cell type distribution of intrathecal antisense oligonucleotide activity in deep brain regions of non-human primates
2025Open Access
Antisense oligonucleotides directed against <i>App</i> and <i>Rab5</i> normalized endosomal Rab activity and reversed DS‐AD‐linked degenerative phenotypes in the Dp16 mouse model of Down syndrome
Alzheimer s & Dementia·2025· 5 citedOpen Access
Atrophin-1 Antisense Oligonucleotide Provides Robust Protection from Pathology in a Fully Humanized DRPLA Model
2025Open Access
Transient Acute Neuronal Activation Response Caused by High Concentrations of Oligonucleotides in the Cerebral Spinal Fluid
2025· 3 citedOpen Access
Antisense oligonucleotide–mediated MSH3 suppression reduces somatic CAG repeat expansion in Huntington’s disease iPSC–derived striatal neurons
Science Translational Medicine·2025· 20 citedOpen Access
Antisense‐mediated APP suppression as potential therapeutic for Down Syndrome Alzheimer’s Disease
Alzheimer s & Dementia·2024Open Access
PrP turnover in vivo and the time to effect of prion disease therapeutics
2024· 3 citedOpen Access
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain
2024· 1 citedOpen Access
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain
2024Open Access
Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain
2024· 7 citedOpen Access
SARM1 activation induces reversible mitochondrial dysfunction and can be prevented in human neurons by antisense oligonucleotides
2024· 5 citedOpen Access
Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain
Acta Neuropathologica Communications·2023· 7 citedOpen Access
ASO‐mediated downregulation of Amyloid Precursor Protein: a new avenue for AD treatment?
Alzheimer s & Dementia·2023Open Access
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Frequent Co-authors

Holly Kordasiewicz(31), Eric E. Swayze(17), Eric Vallabh Minikel(13), Sonia M. Vallabh(13), Andreas Weihofen(9), Curt Mazur(8), Tracy Cole(8), Andrew G. Reidenbach(6), Meredith A Mortberg(6), Juliana E Gentile(6), Andrew B. West(5), Deborah E. Cabin(5), Paymaan Jafar‐Nejad(5), Bethany Fitzsimmons(5), Karli Ikeda-Lee(4), Aneeza Kim(4), Laura A. Volpicelli‐Daley(4), Apoorva Mohan(4), Stuart L. Schreiber(4), Jeffrey B. Carroll(4)