A.P. Turnbull

Great Ormond Street Hospital — United Kingdom

Materials Science · Physical Sciences

23h-index2.3kcitations163works2.22yr avg
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Research Topics

Enzyme Structure and Function(34), Photonic and Optical Devices(15), Semiconductor Lasers and Optical Devices(15), Protein Kinase Regulation and GTPase Signaling(12), Advanced Fiber Laser Technologies(12)

Publications163 total

Evaluation of omalizumab to mepolizumab switch in children and adolescents with severe allergic eosinophilic asthma
2025
<i>ob</i> ABPP-HT*: A Precision-Engineered Activity Proteomics Pipeline for the Streamlined Discovery of Deubiquitinase Inhibitors
2025· 2 citedOpen Access
The differential mechanisms of eIF4A1-mediated translational activation instructed by distinct RNA features
2025Open Access
Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
Journal of Proteome Research·2025· 7 citedOpen Access
Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
2024· 2 citedOpen Access
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
Molecular & Cellular Proteomics·2023· 37 citedOpen Access
Correction to “Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta”
Journal of Medicinal Chemistry·2023· 1 cited
Discovery, Characterization, and Structure-Based Optimization of Small-Molecule In Vitro and In Vivo Probes for Human DNA Polymerase Theta
Journal of Medicinal Chemistry·2022· 41 citedOpen Access
Structural Premise of Selective Deubiquitinase USP30 Inhibition by Small-Molecule Benzosulfonamides
2022· 3 citedOpen Access
Exploring failure management strategies in the international context
Wroclaw University of Economics and Business eBooks·2022Open Access
Author response: USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma
2021Open Access
Studying RNA–Protein Complexes Using X-Ray Crystallography
Methods in molecular biology·2021· 5 cited
USP28 deletion and small molecule inhibition destabilises c-Myc and elicits regression of squamous cell lung carcinoma
2020· 3 citedOpen Access
A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation
Neoplasia·2019· 9 citedOpen Access
Study of dielectric coatings for broadband operation of surface-emitting semiconductor lasers
Journal of the Optical Society of America B·2019· 1 cited
PGK1 in complex with CRT0063465 (3-[2-(4-bromophenyl)-5,7-dimethyl-pyrazolo[1,5-a]pyrimidin-6-yl]propanoic acid)
2018
Abstract LB-B32: Modulation of the Hedgehog signaling pathway in models of basal cell carcinoma by ATP-competitive PKCi inhibitors
Molecular Cancer Therapeutics·2018
Dataset for Tunable repetition rate VECSEL for resonant acoustic-excitation of nanostructures
ePrints Soton (University of Southampton)·2018Open Access
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Nature·2017· 448 cited
A High-Throughput Screening Triage Workflow to Authenticate a Novel Series of PFKFB3 Inhibitors
SLAS DISCOVERY·2017· 14 citedOpen Access
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Frequent Co-authors

David W. Rice(10), Laurent Rigoreau(7), Patrick J. Baker(7), Tony Raynham(6), Jasper Akerboom(6), John van der Oost(6), Svetlana E. Sedelnikova(5), Elisabeth Trivier(5), C. Robin Head(5), Stan J. J. Brouns(4), Jack U. Flanagan(4), Susan M. Boyd(4), Daniel Heinrich(4), Stephen M. F. Jamieson(4), William A. Denny(4), Anne C. Tropper(4), Adán Pinto-Fernández(3), Nicola J. Evans(3), Sheila B. McLoughlin(3), Benedikt M. Kessler(3)