Leticia Colyn

Max Planck Institute of Molecular Cell Biology and Genetics — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index731citations28works3.22yr avg
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Research Topics

Epigenetics and DNA Methylation(5), Liver physiology and pathology(5), Cholangiocarcinoma and Gallbladder Cancer Studies(5), RNA modifications and cancer(5), Liver Disease Diagnosis and Treatment(3)

Publications28 total

Transcriptomic profiling of epigenetic regulators and metabolic reprogramming in human cholangiocarcinoma
2025
<i>Keap1</i> Deletion Rescues Cell Death Associated With <i>Gpx4</i> Loss in Hepatocytes During Acute Liver Injury
Liver International·2025· 3 citedOpen Access
Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
Gut·2024· 14 citedOpen Access
Loss of Toll-like receptor 9 protects from hepatocellular carcinoma in murine models of chronic liver disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2024· 2 citedOpen Access
FRI-522 Loss of Toll-like receptor 9 protects from hepatocellular carcinoma in murine models of chronic liver disease
Journal of Hepatology·2024
TLR9 deletion rescues cell death associated fibrosis- and hepatocarcinoma progression in models of liver injury
Zeitschrift für Gastroenterologie·2024
Kelch-like ECH-associated protein-1 deletion rescues cell death associated with glutathione-glutathione peroxidase 4 knockdown in hepatocytes in acute models of liver injury
Journal of Hepatology·2023
The inhibition of the epigenetic efectors DNMT1 and G9a as a potential therapeutic strategy against the non-alcoholic fatty liver development
Journal of Hepatology·2022
Proteomic analysis of bile in the rat thioacetamide model reveals new mechanisms in human cholangiocarcinogenesis
Journal of Hepatology·2022
New molecular mechanisms in cholangiocarcinoma: signals triggering interleukin-6 production in tumor cells and KRAS co-opted epigenetic mediators driving metabolic reprogramming
Journal of Experimental & Clinical Cancer Research·2022· 32 citedOpen Access
Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease
Cancers·2021· 5 citedOpen Access
Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge
Oncogene·2021· 10 citedOpen Access
Dual Pharmacological Targeting of HDACs and PDE5 Inhibits Liver Disease Progression in a Mouse Model of Biliary Inflammation and Fibrosis
Cancers·2020· 15 citedOpen Access
Dual Targeting of G9a and DNA Methyltransferase‐1 for the Treatment of Experimental Cholangiocarcinoma
Hepatology·2020· 60 cited
Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target?
Cells·2020· 37 citedOpen Access
Epigenetics in hepatocellular carcinoma development and therapy: The tip of the iceberg
JHEP Reports·2020· 120 citedOpen Access
Dual inhibition of DNA methyltransferase 1 and the histone methyltransferase G9a as a new therapeutic strategy in hepatoblastoma
Journal of Hepatology·2020Open Access
The splicing regulator SLU7 is required for DNMT1 protein stability and DNA methylation maintenance
Journal of Hepatology·2020
SLU7 downregulation potentiates liver damage through hepatic de-differentiation
Journal of Hepatology·2020Open Access
Epigenetic mechanism and metabolic reprogramming in fibrogenesis: dual targeting of G9a and DNA methyltransferase 1 for the inhibition of liver fibrosis
Journal of Hepatology·2020Open Access
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Frequent Co-authors

Maite G. Fernández‐Barrena(21), Carmen Berasain(20), Matías A. Ávila(20), María Arechederra(19), María U. Latasa(18), Iker Uriarte(15), Bruno Sangro(13), Marina Bárcena‐Varela(10), Gloria Álvarez‐Sola(8), Jesús Urmán(8), Julen Oyarzábal(7), José J.G. Marı́n(7), Maria Luz Martínez‐Chantar(7), Francisco Javier Cubero(7), Christian Trautwein(7), Eva Santamaría(6), Alex Clavería-Cabello(6), María J. Iraburu(6), Jesús M. Bañales(6), Felipe Prósper(5)