Jan Fiedler

Fraunhofer Institute for Translational Medicine and Pharmacology — Germany

Biochemistry, Genetics and Molecular Biology · Life Sciences

40h-index9.5kcitations114works5.22yr avg
OpenAlex↗ORCID↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

MicroRNA in disease regulation(47), Circular RNAs in diseases(29), Cancer-related molecular mechanisms research(23), RNA Research and Splicing(9), Extracellular vesicles in disease(9)

Publications113 total

Increase in mechanical load and pro-fibrotic stimulation leads to fibrotic and hypertrophic remodeling in porcine living myocardial slices
Scientific Reports·2025Open Access
Integrating Heart-on-Chip Technology and 3D Porcine Living Myocardial Slices for Cardiotoxicity Screening
Current Directions in Biomedical Engineering·2025Open Access
Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase
Journal of Medicinal Chemistry·2025· 7 citedOpen Access
Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung
Frontiers in Pharmacology·2025· 2 citedOpen Access
Evaluating the Role of AMB-05X in Modulating Key Fibrotic Markers in Human Precision-cut Lung Slices
American Journal of Respiratory and Critical Care Medicine·2025
Molecular and Mechanical Biomarker Integration in a Preclinical Lung Model to Advance Anti-Fibrotic Therapies
American Journal of Respiratory and Critical Care Medicine·2025
Anti-fibrotic effects on extracellular matrix remodeling ex vivo: Insights from human lung slices and extended microphysiological system culture
2025
Patient-specific hiPSC-derived cardiomyocytes indicate allelic and contractile imbalance as pathogenic factor in early-stage Hypertrophic Cardiomyopathy
Journal of Molecular and Cellular Cardiology·2024· 2 cited
De novo establishment of an ex vivo culture for living myocardial slices applying a microphysiological system – MPSlms
Current Directions in Biomedical Engineering·2024· 1 citedOpen Access
Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine
Journal of Molecular and Cellular Cardiology·2024· 7 citedOpen Access
Understanding the Dynamics of Pro-Fibrotic Biomarkers in Precision-Cut Lung Slices: Implications for Preclinical Studies
2024
Single-nucleus RNA sequencing identifies cell-type–specific effects of sodium-glucose co-transporter 2 inhibitors in human myocardial slices
European Heart Journal·2024· 12 citedOpen Access
SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation
Scientific Reports·2024· 12 citedOpen Access
Inhibition of miR-21: cardioprotective effects in human failing myocardium <i>ex vivo</i>
European Heart Journal·2024· 19 citedOpen Access
The role of fibrosis in cardiomyopathies: An opportunity to develop novel biomarkers of disease activity
Matrix Biology·2024· 7 cited
Automated High-Throughput Live Cell Monitoring of Scratch Wound Closure
Biomedical Engineering and Computational Biology·2024· 3 citedOpen Access
SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation
2023Open Access
Automated high-throughput live cell monitoring of endothelial cell migration
2023Open Access
Preservation of Relevant Signaling Pathways in the Living Precision Cut Lung Slices of Patients With Pulmonary Fibrosis
2023
Mass spectrometry-based proteomics analysis of rat living myocardial slices subjected to cryoinjury.
Figshare·2023Open Access
page 1 of 6Next →

Frequent Co-authors

Thomas Thum(48), Annette Just(11), Johann Bauersachs(10), Shashi Kumar Gupta(9), Sándor Bátkai(8), Ariana Foinquinos(8), Paolo Galuppo(7), Claudia Bang(7), Johan M. Lorenzen(7), Ke Xiao(7), Angelika Pfanne(7), Seema Dangwal(6), Angelika Holzmann(6), Regalla Kumarswamy(6), Stefan Engelhardt(5), Janet Remke(5), Karina Zimmer(5), Susanne Kneitz(5), Dorothee Hartmann(5), Manuel Mayr(4)