Barbara L. Hempstead

Cornell University — United States

Neuroscience · Life Sciences

77h-index28.5kcitations161works0.32yr avg
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Research Topics

Nerve injury and regeneration(108), Neurogenesis and neuroplasticity mechanisms(49), Signaling Pathways in Disease(30), RNA Interference and Gene Delivery(21), Neuropeptides and Animal Physiology(16)

Publications161 total

Expression of the human immunomodulatory protein, human B7-1 (CD80), accelerates neuroinflammation, synaptic loss, microvascular instability and lethality in a murine model of Alzheimer’s Disease
2025Open Access
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease
Nature Communications·2025Open Access
Aβ-induced distress of astrocytes triggers Alzheimer disease pathology through non-canonical δ secretase activity
2025· 1 citedOpen Access
Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation
Frontiers in Molecular Neuroscience·2023· 4 citedOpen Access
Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor
Journal of Clinical Investigation·2022· 8 citedOpen Access
Small, Nonpeptide p75NTR Ligands Induce Survival Signaling and Inhibit proNGF-Induced Death
UNC Libraries·2021· 9 citedOpen Access
A Molecular Redox Switch on p21 ras: STRUCTURAL BASIS FOR THE NITRIC OXIDE-p21rasINTERACTION
UNC Libraries·2021· 24 citedOpen Access
SorCS is highly expressed in the CA2 region of the hippocampus and is enriched in the postsynaptic region
Molecular Psychiatry·2021
Zinc induced structural changes in the intrinsically disordered BDNF Met prodomain confer synaptic elimination
Metallomics·2020· 6 citedOpen Access
SorCS2 is required for social memory and trafficking of the NMDA receptor
Molecular Psychiatry·2020· 39 citedOpen Access
BDNF Actions in the Cardiovascular System: Roles in Development, Adulthood and Response to Injury
Frontiers in Physiology·2019· 80 citedOpen Access
New Roles for an Ancient Factor
Trends in Neurosciences·2018· 5 cited
The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior
Neuron·2018· 19 citedOpen Access
The BDNF Val66Met Prodomain Disassembles Dendritic Spines Altering Fear Extinction Circuitry and Behavior
Neuron·2018· 64 citedOpen Access
A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75<sup>NTR</sup>-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death<i>In Vitro</i>and<i>In Vivo</i>
eNeuro·2018· 16 citedOpen Access
Effect of Early-Life Fluoxetine on Anxiety-Like Behaviors in BDNF Val66Met Mice
American Journal of Psychiatry·2017· 23 citedOpen Access
Narp Mediates Antidepressant-Like Effects of Electroconvulsive Seizures
Neuropsychopharmacology·2017· 23 citedOpen Access
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington’s disease
JCI Insight·2017· 39 citedOpen Access
Autocrine BDNF–TrkB signalling within a single dendritic spine
Nature·2016· 321 citedOpen Access
Faculty Opinions recommendation of Glycolytic Enzymes Localize to Synapses under Energy Stress to Support Synaptic Function.
Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature·2016Open Access
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Frequent Co-authors

Moses V. Chao(11), Kenneth K. Teng(9), Francis S. Lee(8), Bai Lu(6), Ramee Lee(5), Zhe-Yu Chen(5), Henry Teng(5), Rosemary Kraemer(5), Pouneh Kermani(4), Luis F. Parada(4), Deqiang Jing(4), Chia-Jen Siao(4), Anders Nykjær(4), David R. Kaplan(3), Kevin G. Bath(3), Harry M. Lander(3), Jianmin Yang(3), Guhan Nagappan(3), Lino Tessarollo(3), Michael J. Donovan(3)