Carl Laxton

Medicine · Health Sciences

14h-index2.0kcitations23works0.02yr avg
OpenAlex↗Google Scholar↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Hepatitis C virus research(14), Immune Response and Inflammation(8), Influenza Virus Research Studies(6), Cytokine Signaling Pathways and Interactions(5), Hepatitis B Virus Studies(3)

Publications23 total

Use of qualitative integrative cycler PCR (qicPCR) to identify optimal therapeutic dosing time-points in a Respiratory Syncytial Virus Human Viral Challenge Model (hVCM)
Journal of Virological Methods·2015· 8 cited
Therapy with TLR7 Agonists Induces Lymphopenia: Correlating Pharmacology to Mechanism in a Mouse Model
Journal of Clinical Immunology·2012· 24 cited
Discovery of a highly potent series of TLR7 agonists
Bioorganic & Medicinal Chemistry Letters·2011· 20 citedOpen Access
Selection, Optimization, and Pharmacokinetic Properties of a Novel, Potent Antiviral Locked Nucleic Acid-Based Antisense Oligomer Targeting Hepatitis C Virus Internal Ribosome Entry Site
Antimicrobial Agents and Chemotherapy·2011· 53 cited
The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)
Clinical Pharmacology & Therapeutics·2011· 70 cited
Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection
Bioorganic & Medicinal Chemistry Letters·2011· 27 citedOpen Access
The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection
MedChemComm·2010· 17 cited
Use of a highly sensitive strand-specific quantitative PCR to identify abortive replication in the mouse model of respiratory syncytial virus disease
Virology Journal·2010· 19 citedOpen Access
868 EVALUATION OF THE IMMUNOSTIMULATORY ACTIONS OF THE TLR7 AGONIST SM-360320 IN EX VIVO ASSAYS IN THE BLOOD OF HCV PATIENTS AND HEALTHY DONORS
Journal of Hepatology·2009Open Access
Comparison of Rat and Human Responses to Toll-Like Receptor 7 Activation
Journal of Interferon & Cytokine Research·2008· 6 cited
Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection
Antimicrobial Agents and Chemotherapy·2007· 66 citedOpen Access
Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479
Bioorganic & Medicinal Chemistry Letters·2007· 96 cited
The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture
Journal of Biological Chemistry·2005· 215 citedOpen Access
Use of the HCV subgenomic replicon for the selection and characterisation of variants with reduced susceptibility to interferon alfa-2a
Gastroenterology·2001
Characterisation of interferon alfa-2a and pegylated interferon alfa-2A in combination with ribavirin, mycophenolic acid or VX-497 as inhibitors of HCV replicon replication
Journal of Hepatology·2001· 3 cited
Use of the HCV subgenomic replicon for the selection and characterization of variants with reduced susceptibility to interferon alpha-2A
Journal of Hepatology·2001· 2 cited
Selection of HCV NS5A quasispecies during IFN therapy in patients with chronic HCV.
Digestive Diseases and Sciences·2001· 7 cited
Hepatitis C virus NS5A protein inhibits interferon antiviral activity, but the effects do not correlate with clinical response
Gastroenterology·1999· 81 citedOpen Access
Expression and characterization of the hepatitis G virus helicase
Journal of Viral Hepatitis·1998· 13 cited
Functional differences in the promoters of the interferon‐inducible (2′‐5′)A oligoadenylate synthetase and 6–16 genes in interferon‐resistant Daudi cells
European Journal of Biochemistry·1994· 14 cited
page 1 of 2Next →

Frequent Co-authors

Nigel Horscroft(7), Tanya Parkinson(6), René Devos(5), Isabel Nájera(5), Julian Symons(4), A. K. Thomas(4), David C. Pryde(4), Ian M. Kerr(3), Andrew M. Ackrill(3), Graham R. Foster(3), Mark Fidock(3), Jaiessh Rawal(3), Edward J. Murray(3), Thien-Duc Tran(3), Peter Jones(3), Fiona M. Adam(3), Gerwyn Bish(3), Frederick Calo(3), Jonathan Duckworth(3), David Fox(3)