José G. Castaño

Consejo Superior de Investigaciones Científicas — Spain

Biochemistry, Genetics and Molecular Biology · Life Sciences

29h-index3.0kcitations64works0.02yr avg
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Research Topics

Ubiquitin and proteasome pathways(20), Parkinson's Disease Mechanisms and Treatments(14), Endoplasmic Reticulum Stress and Disease(12), Pancreatic function and diabetes(7), Peptidase Inhibition and Analysis(7)

Publications64 total

Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson's disease-associated DJ-1/PARK 7 missense mutants
Scientific Reports·2021· 17 citedOpen Access
Mitochondrial LonP1 protease is implicated in the degradation of unstable Parkinson disease-associated DJ-1/PARK 7 missense mutants
2020Open Access
Correction: Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein
PLoS ONE·2020Open Access
Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein
PLoS ONE·2018· 4 citedOpen Access
Inhibitors of lysosomal function or serum starvation in control or LAMP2 deficient cells do not modify the cellular levels of Parkinson disease-associated DJ-1/PARK 7 protein
2018Open Access
Lysine-Less Variants of Spinal Muscular Atrophy SMN and SMNΔ7 Proteins Are Degraded by the Proteasome Pathway
International Journal of Molecular Sciences·2017· 4 citedOpen Access
CCAAT/Enhancer binding protein β silencing mitigates glial activation and neurodegeneration in a rat model of Parkinson’s disease
Scientific Reports·2017· 15 citedOpen Access
Protein degradation in a LAMP-2-deficient B-lymphoblastoid cell line from a patient with Danon disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease·2016· 4 cited
Cytomegalovirus promoter up-regulation is the major cause of increased protein levels of unstable reporter proteins after treatment of living cells with proteasome inhibitors.
Journal of Biological Chemistry·2016Open Access
α-Synuclein expression levels do not significantly affect proteasome function and expression in mice and stably transfected PC12 cell lines.
Journal of Biological Chemistry·2016· 1 citedOpen Access
Proteins Directly Interacting with Mammalian 20S Proteasomal Subunits and Ubiquitin-Independent Proteasomal Degradation
Biomolecules·2014· 28 citedOpen Access
Mechanism of cleavage of alpha-synuclein by the 20S proteasome and modulation of its degradation by the RedOx state of the N-terminal methionines
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2013· 65 cited
Molecular Pathogenesis and Pathophysiology of Parkinson’s Disease: New Targets for New Therapies
2013· 1 cited
The N-Terminal Region of Nurr1 (a.a 1–31) Is Essential for Its Efficient Degradation by the Ubiquitin Proteasome Pathway
PLoS ONE·2013· 15 citedOpen Access
A Critical Appraisal of Quantitative Studies of Protein Degradation in the Framework of Cellular Proteostasis
Biochemistry Research International·2012· 30 citedOpen Access
Reduced protein stability of human DJ-1/PARK7 L166P, linked to autosomal recessive Parkinson disease, is due to direct endoproteolytic cleavage by the proteasome
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research·2011· 32 cited
Animal Models and the Pathogenesis of Parkinson's Disease
2011
Chapter 7. Animal Models and the Pathogenesis of Parkinson's Disease
RSC drug discovery/RSC drug discovery series·2011
Mechanism of α-synuclein cleavage by the 20S proteasome. Inhibition of α-synuclein degradation by oxidation of its N-terminal methionines and reversion by methionine sulforeductase A
2011
Synphilin-1 inhibits alpha-synuclein degradation by the proteasome
Cellular and Molecular Life Sciences·2010· 36 citedOpen Access
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Frequent Co-authors

Beatriz Alvarez‐Castelao(11), P. Arizti(8), Joaquı́n Arribas(8), Isabel Mayo(6), Raúl Sánchez‐Lanzas(6), Amelia Nieto(4), Isidró Ferrer(3), José J. Lucas(3), Susana Alemany(3), José M. Mato(3), E. Mira(3), Miguel Díaz‐Hernández(2), Félix Hernández(2), Pilar Gómez‐Ramos(2), María A. Morán(2), Miguel Lafarga(2), Marı́a T. Berciano(2), Janet Tobian(2), Michael Zasloff(2), Esther Mahillo(2)