Aaron Ciechanover

Rappaport Family Institute for Research in the Medical Sciences — Israel

Biochemistry, Genetics and Molecular Biology · Life Sciences

106h-index63.6kcitations404works3.52yr avg
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Research Topics

Ubiquitin and proteasome pathways(256), Autophagy in Disease and Therapy(81), Cancer-related Molecular Pathways(68), Protein Degradation and Inhibitors(45), Endoplasmic Reticulum Stress and Disease(43)

Publications403 total

Proteolysis targeting chimeric-based technology in myeloma and lymphoma
Molecular Cancer Therapeutics·2026Open Access
Ubiquitin E3 ligase KPC1 governs mesenchymal metastatic melanoma reprogramming via proteasomal degradation of ZEB1
Cell Death and Disease·2025Open Access
Regulation via compartmentation: adaptive localization of the proteasome under stress
Biochemical Society Transactions·2025Open Access
Role of p62 nuclear condensates in regulating <b>ubiquitin-mediated proteasomal degradation</b>
Essays in Biochemistry·2025· 2 citedOpen Access
Discovery of a potent covalent inhibitor that unusually distorts the catalytic dyad of SARS-CoV-2 main protease
Journal of Virology·2025· 2 citedOpen Access
Protein quality control systems in neurodegeneration – culprits, mitigators, and solutions?
Frontiers in Neurology·2025· 3 citedOpen Access
Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma
Biomarker Research·2025· 2 citedOpen Access
The cryo-EM-delineated mechanism underlying mimicry of CXCR4 agonism enables widespread stem cell neuroprotection in a mouse model of ALS
2025Open Access
Bone Marrow-Targeted Liposomes Loaded with Bortezomib Overcome Multiple Myeloma Resistance
ACS Nano·2025· 6 citedOpen Access
Vimentin is a ubiquitination and degradation substrate of the ubiquitin ligase KPC1
Biochemical and Biophysical Research Communications·2024· 4 cited
CXCL12 restricts tumor growth by suppressing the Ras, ERK1/2, c-Myc, and the immune checkpoint PD-L1 pathways
Proceedings of the National Academy of Sciences·2024· 11 citedOpen Access
Nuclear p62 condensates stabilize the promyelocytic leukemia nuclear bodies by sequestering their ubiquitin ligase RNF4
Proceedings of the National Academy of Sciences·2024· 6 citedOpen Access
Inhibition of nucleo-cytoplasmic proteasome translocation by the aromatic amino acids or silencing Sestrin3—their sensing mediator—is tumor suppressive
Cell Death and Differentiation·2024· 11 citedOpen Access
Discovery of Novel Nonpeptidic Proteasome Inhibitors Using Covalent Virtual Screening and Biological Evaluation
ACS Medicinal Chemistry Letters·2024· 2 citedOpen Access
A024 Investigating the role of the Huntingtin ubiquitination sites K6 and K9 in a novel mouse model of Huntington disease
2024Open Access
Peripheral sequestration of huntingtin delays neuronal death and depends on N-terminal ubiquitination
Communications Biology·2024· 5 citedOpen Access
Reflections from Nobel laureates in chemistry
Cell chemical biology·2024
Personalized medicine: the future is here
Croatian Medical Journal·2024· 6 citedOpen Access
Stress-Induced Proteasome Sub-Cellular Translocation in Cardiomyocytes Causes Altered Intracellular Calcium Handling and Arrhythmias
International Journal of Molecular Sciences·2024· 3 citedOpen Access
Moral clarity at WHO needs to be clearer
The Lancet·2024· 2 citedOpen Access
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Frequent Co-authors

Alan L. Schwartz(8), Avram Hershko(7), Ilio Vitale(4), Stuart A. Aaronson(4), John Abrams(4), Emad S. Alnemri(4), David W. Andrews(4), Eric H. Baehrecke(4), Nicolás G. Bazán(4), Mikhail V. Blagosklonny(4), Klas Blomgren(4), Christoph Borner(4), Catherine Brenner(4), John A. Cidlowski(4), Ruggero De Maria(4), Brian David Dynlacht(4), Wafik S. El‐Deiry(4), Carmen Garrido(4), Hinrich Gronemeyer(4), J. Marie Hardwick(4)