Rob A. van der Kammen

The Netherlands Cancer Institute — Netherlands

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index6.3kcitations31works0.02yr avg
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Research Topics

Protein Kinase Regulation and GTPase Signaling(16), Cell Adhesion Molecules Research(9), Cellular Mechanics and Interactions(8), Wnt/β-catenin signaling in development and cancer(6), PI3K/AKT/mTOR signaling in cancer(4)

Publications31 total

Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling
Journal of Cell Science·2009· 28 cited
The Rac activator Tiam1 controls efficient T-cell trafficking and route of transendothelial migration
Blood·2009· 94 cited
The Par-Tiam1 Complex Controls Persistent Migration by Stabilizing Microtubule-Dependent Front-Rear Polarity
Current Biology·2007· 173 citedOpen Access
The Par polarity complex regulates Rap1- and chemokine-induced T cell polarization
The Journal of Cell Biology·2007· 124 citedOpen Access
The Rac activator Tiam1 is required for α3β1-mediated laminin-5 deposition, cell spreading, and cell migration
The Journal of Cell Biology·2005· 98 citedOpen Access
The Rac Activator Tiam1 Is a Wnt-responsive Gene That Modifies Intestinal Tumor Development
Journal of Biological Chemistry·2005· 128 citedOpen Access
RhoA activation promotes transendothelial migration of monocytes via ROCK
Journal of Leukocyte Biology·2003· 93 cited
Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours
Nature·2002· 383 cited
Rho family proteins in cell adhesion and cell migration
European Journal of Cancer·2000· 238 cited
Oncogenic Ras Downregulates Rac Activity, Which Leads to Increased Rho Activity and Epithelial–Mesenchymal Transition
The Journal of Cell Biology·2000· 289 citedOpen Access
Expression of Rho GTPases using retroviral vectors
Methods in enzymology on CD-ROM/Methods in enzymology·2000· 47 cited
Rho-like GTPases in tumor cell invasion
Methods in enzymology on CD-ROM/Methods in enzymology·2000· 31 cited
Rac Downregulates Rho Activity
The Journal of Cell Biology·1999· 835 citedOpen Access
Rac regulates phosphorylation of the myosin-II heavy chain, actinomyosin disassembly and cell spreading
Nature Cell Biology·1999· 216 cited
Matrix-dependent Tiam1/Rac Signaling in Epithelial Cells Promotes Either Cell–Cell Adhesion or Cell Migration and Is Regulated by Phosphatidylinositol 3-Kinase
The Journal of Cell Biology·1998· 658 citedOpen Access
Invasion of T-lymphoma cells: cooperation between Rho family GTPases and lysophospholipid receptor signaling
The EMBO Journal·1998· 221 citedOpen Access
Inhibition of Invasion of Epithelial Cells by Tiam1-Rac Signaling
Science·1997· 438 cited
The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho
The Journal of Cell Biology·1997· 358 citedOpen Access
Targeting of Tiam1 to the Plasma Membrane Requires the Cooperative Function of the N-terminal Pleckstrin Homology Domain and an Adjacent Protein Interaction Domain
Journal of Biological Chemistry·1997· 143 citedOpen Access
Regulated Membrane Localization of Tiam1, Mediated by the NH2-terminal Pleckstrin Homology Domain, Is Required for Rac-dependent Membrane Ruffling and C-Jun NH2-terminal Kinase Activation
The Journal of Cell Biology·1997· 229 citedOpen Access
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Frequent Co-authors

John G. Collard(20), Frits Michiels(11), Gaston Habets(10), J.G. Collard(10), Jean Paul ten Klooster(6), Jord C. Stam(6), Frank N. van Leeuwen(5), Eva E. Sander(3), Sanne van Delft(3), Angeliki Malliri(3), Hendrie E.T. Kain(3), Eva E. Evers(3), Alexander E.E. Mertens(3), Ellen H.M. Scholtes(2), Peter L. Hordijk(2), Gerben Zondag(2), Lennert Janssen(2), D. Michiel Pegtel(2), Saskia I. J. Ellenbroek(2), Audrey Gérard(2)