C. Roland Wolf

Brigham and Women's Hospital — United States

Pharmacology, Toxicology and Pharmaceutics · Life Sciences

90h-index32.3kcitations720works5.02yr avg
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Research Topics

Pharmacogenetics and Drug Metabolism(276), Glutathione Transferases and Polymorphisms(152), Drug Transport and Resistance Mechanisms(107), Genomics, phytochemicals, and oxidative stress(93), Estrogen and related hormone effects(47)

Publications717 total

Humanization of Drug Metabolism in the <i>Plasmodium berghei</i> Mouse Model for Antimalarial Drug Discovery
ACS Infectious Diseases·2025Open Access
Integration of in vivo stress reporters with transcription profiling to define chemical mixtures mechanisms of toxicity, including trans-generational effects
Chemico-Biological Interactions·2025Open Access
Application of a mouse model humanized for cytochrome P450–mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs
Drug Metabolism and Disposition·2025· 1 citedOpen Access
A 10-Year Retrospective and Prospective Assessment of Trends in Electricity Supply and Demand and Associated Water Consumption in the Great Lakes St. Lawrence Region
Deep Blue (University of Michigan)·2025Open Access
The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals
Archives of Toxicology·2025· 3 citedOpen Access
1315 Co-staining of CD34 and p53 in Acute Myeloid Leukemia Reveals Heterogeneity of Cell Types Expressing Mutant p53 with Potential Prognostic Implications
Laboratory Investigation·2025Open Access
Use of an extensively humanized mouse model to predict the risk of drug–drug interactions in patients receiving dexamethasone
Journal of Pharmacology and Experimental Therapeutics·2024· 4 citedOpen Access
Molecular Genetics of Drug Resistance
2024· 30 cited
Novel <i>in vivo</i> TDP-43 stress reporter models to accelerate drug development in ALS
Open Biology·2024· 1 citedOpen Access
Author response for "Novel &lt;i&gt;in vivo&lt;/i&gt; TDP-43 stress reporter models to accelerate drug development in ALS"
2024
Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies
npj Systems Biology and Applications·2024· 5 citedOpen Access
Acceleration of infectious disease drug discovery and development using a humanized model of drug metabolism
Proceedings of the National Academy of Sciences·2024· 21 citedOpen Access
Editorial
Zeitschrift für Arbeitsrecht·2024
Novel <i>in vivo</i> TDP-43 stress reporter models to accelerate drug development in ALS
2023Open Access
Simulating BRAFV600E-MEK-ERK signalling dynamics in response to vertical inhibition treatment strategies
2023Open Access
Inhalt
Zeitschrift für Arbeitsrecht·2023Open Access
Nachruf für Bernd Rüthers
Zeitschrift für Arbeitsrecht·2023
Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies
F1000Research·2023· 2 citedOpen Access
Inhalt
Zeitschrift für Arbeitsrecht·2023Open Access
Defining the in vivo mechanism of air pollutant toxicity using murine stress response biomarkers
The Science of The Total Environment·2023· 6 citedOpen Access
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Frequent Co-authors

Colin J. Henderson(18), John D. Hayes(10), Gillian Smith(6), Lesley M. Forrester(4), Michael J. Glancey(4), Michael McMahon(3), Masayuki Yamamoto(3), Simon A. Chanas(3), Diana M. E. Otto(3), Aileen McLaren(3), Thomas Friedberg(3), B Ketterer(2), Ken Itoh(2), Lesley I. McLellan(2), Daniel W. Nebert(2), Tracy Lightfoot(2), R. Steele(2), Clifford R. Elcombe(2), Graeme J. Moffat(2), Nigel K. Spurr(2)