Alexis Bretteville

Johnson & Johnson (United States) — United States

Medicine · Health Sciences

25h-index2.5kcitations41works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(27), Neuroscience and Neuropharmacology Research(13), Cholinesterase and Neurodegenerative Diseases(8), Nerve injury and regeneration(4), Prion Diseases and Protein Misfolding(4)

Publications41 total

Development and validation of a robust UPLC-MS/MS method for the analysis of polyamines in cells, biofluids and tissues
Journal of Pharmaceutical and Biomedical Analysis·2026
IP-LC-MSMS Enables Identification of Three Tau <i>O</i>-GlcNAcylation Sites as <i>O</i>-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau
Journal of Proteome Research·2023· 3 cited
Diazaspirononane Nonsaccharide Inhibitors of O-GlcNAcase (OGA) for the Treatment of Neurodegenerative Disorders
Journal of Medicinal Chemistry·2020· 21 citedOpen Access
Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes
Stem Cell Reports·2019· 3 citedOpen Access
Additional file 11: of Tau phosphorylation regulates the interaction between BIN1â s SH3 domain and Tauâ s proline-rich domain
Figshare·2019Open Access
Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes
Stem Cell Reports·2018· 64 citedOpen Access
Systemic immune‐checkpoint blockade with anti‐PD1 antibodies does not alter cerebral amyloid‐β burden in several amyloid transgenic mouse models
Glia·2017· 58 cited
Proximity Ligation Assay: A Tool to Study Endogenous Interactions Between Tau and Its Neuronal Partners
Methods in molecular biology·2016· 4 cited
Functional screening of Alzheimer risk loci identifies PTK2B as an in vivo modulator and early marker of Tau pathology
Molecular Psychiatry·2016· 113 citedOpen Access
Development of a Scalable, High-Throughput-Compatible Assay to Detect Tau Aggregates Using iPSC-Derived Cortical Neurons Maintained in a Three-Dimensional Culture Format
SLAS DISCOVERY·2016· 72 citedOpen Access
Tau phosphorylation regulates the interaction between BIN1’s SH3 domain and Tau’s proline-rich domain
Acta Neuropathologica Communications·2015· 84 citedOpen Access
Dexmedetomidine increases tau phosphorylation under normothermic conditions in vivo and in vitro
Neurobiology of Aging·2015· 32 citedOpen Access
P4‐032: MOLECULAR CHARACTERISATION OF BRIDGING INTEGRATOR 1 (BIN1) INTERACTION WITH TAU
Alzheimer s & Dementia·2014
Specificity of Anti-Tau Antibodies when Analyzing Mice Models of Alzheimer's Disease: Problems and Solutions
PLoS ONE·2014· 143 citedOpen Access
Insulin dysfunction and Tau pathology
Frontiers in Cellular Neuroscience·2014· 126 citedOpen Access
Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK/MAPK inactivation
Scientific Reports·2013· 32 citedOpen Access
Anesthesia and tau pathology
Progress in Neuro-Psychopharmacology and Biological Psychiatry·2013· 98 citedOpen Access
Deregulation of Protein Phosphatase 2A and Hyperphosphorylation of τ Protein Following Onset of Diabetes in NOD Mice
Diabetes·2012· 61 citedOpen Access
Tau pathology modulates Pin1 post-translational modifications and may be relevant as biomarker
Neurobiology of Aging·2012· 19 cited
P3‐001: Hypothermia‐induced hyperphosphorylation: A new model to study tau kinase inhibitors
Alzheimer s & Dementia·2012· 3 citedOpen Access
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Frequent Co-authors

Luc Buée(15), Emmanuel Planel(14), Malika Hamdane(11), Séverine Bégard(10), Katharina Schindowski(9), Pierre Dourlen(9), Kunié Ando(8), Nicolas Sergeant(7), Robert A. Whittington(6), Andreas Ebneth(6), François Marcouiller(6), Carl Julien(6), Karelle Leroy(5), Jean‐Pierre Brion(5), André Delacourte(5), Franck R. Petry(5), Julien Chapuis(5), Marie‐Christine Galas(5), Guy Lippens(5), Isabelle Landrieu(5)