Nathalie Delesque

Sanofi (France) — France

Medicine · Health Sciences

14h-index1.5kcitations20works0.02yr avg
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Research Topics

Neuroendocrine Tumor Research Advances(12), Protein Tyrosine Phosphatases(8), Angiogenesis and VEGF in Cancer(3), Glycosylation and Glycoproteins Research(3), PI3K/AKT/mTOR signaling in cancer(3)

Publications20 total

Aflibercept exhibits VEGF binding stoichiometry distinct from bevacizumab and does not support formation of immune-like complexes
Angiogenesis·2016· 42 citedOpen Access
<i>N</i>-[6-(4-Butanoyl-5-methyl-1<i>H</i>-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1<i>H</i>-indole-3-carboxamide (SAR216471), a Novel Intravenous and Oral, Reversible, and Directly Acting P2Y12 Antagonist
Journal of Medicinal Chemistry·2014· 49 citedOpen Access
VEGF Trap Exhibits VEGF Binding Stoichiometry Distinct From Antibodies, and Does Not Support Platelet Aggregation
Investigative Ophthalmology & Visual Science·2012
A Tyrosine Phosphatase is Associated with the Somatostatin Receptor
Novartis Foundation symposium·2007· 16 cited
VEGF‐R2 and neuropilin‐1 are involved in VEGF‐A‐induced differentiation of human bone marrow progenitor cells
Journal of Cellular Physiology·2004· 32 cited
P2Y12, a New Platelet ADP Receptor, Target of Clopidogrel
Biochemical and Biophysical Research Communications·2001· 270 cited
Gene Therapy for Pancreatic Carcinoma: Local and Distant Antitumor Effects after Somatostatin Receptor sst2 Gene Transfer
Human Gene Therapy·1999· 92 cited
Gene transfer of SST2 somatostatin receptor: A model of gene therapy for pancreatic cancer
Gastroenterology·1998Open Access
sst2 Somatostatin Receptor Mediates Negative Regulation of Insulin Receptor Signaling through the Tyrosine Phosphatase SHP-1
Journal of Biological Chemistry·1998· 112 citedOpen Access
The Tyrosine Phosphatase SHP-1 Associates with the sst2 Somatostatin Receptor and Is an Essential Component of sst2-mediated Inhibitory Growth Signaling
Journal of Biological Chemistry·1997· 166 citedOpen Access
Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5
Proceedings of the National Academy of Sciences·1997· 138 citedOpen Access
sst2 somatostatin receptor expression reverses tumorigenicity of human pancreatic cancer cells.
PubMed·1997· 105 cited
Characterization of the antiproliferative signal mediated by the somatostatin receptor subtype sst5 (cyclic GMPycholecystokinin receptorymitogen-activated protein kinaseysomatostatin analogue RC-160ydecreased cell growth)
1997
Role du recepteur de somatostatine de type 2 (sst2) dans le signal antiproliferatif de la somatostatine
Head and Neck Pathology·1997
Molecular mechanisms of antiproliferative effect of somatostatin: Involvement of a tyrosine phosphatase
Metabolism·1996· 39 cited
Induction of a negative autocrine loop by expression of sst2 somatostatin receptor in NIH 3T3 cells.
Journal of Clinical Investigation·1996· 52 citedOpen Access
Expression of SSTR2 somatostatin receptor subtype inhibted pancreatic tumor cell growth
Gastroenterology·1995Open Access
Association of tyrosine phosphatase SHPTP1 to SSTR2 somatostatin receptor subtype
Gastroenterology·1995Open Access
Up-regulation of somatostatin receptors by epidermal growth factor and gastrin in pancreatic cancer cells.
Molecular Pharmacology·1994· 46 cited
Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediation by human somatostatin receptor subtypes SSTR1 and SSTR2.
Proceedings of the National Academy of Sciences·1994· 330 citedOpen Access

Frequent Co-authors

Louis Buscail(13), Nathalie Saint‐Laurent(11), Nicole Vaysse(11), J.P. Estève(8), Christiane Susini(8), Andrew V. Schally(5), C. Susini(5), Pierre Savi(4), Frédéric Lopez(4), Isabelle Rauly(4), Françoise Bono(4), Jean‐Marc Herbert(3), Jean‐Pierre Estève(3), Corinne Bousquet(3), Graeme I. Bell(2), Pierre Cordelier(2), Philippe Rochaix(2), Jean-Pascal Hérault(2), M. Zeggari(2), Douglas MacDonald(2)