James G. Begley

University of Kentucky — United States

Medicine · Health Sciences

15h-index3.0kcitations21works0.02yr avg
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Research Topics

Alzheimer's disease research and treatments(7), Neuroscience and Neuropharmacology Research(5), Mitochondrial Function and Pathology(4), Cell death mechanisms and regulation(3), RNA Interference and Gene Delivery(2)

Publications21 total

The isoflavone genistein inhibits LPS-stimulated TNFa, but not IL-6 expression in monocytes from hemodialysis patients and healthy subjects
Clinical Nephrology·2006· 6 cited
Anti-apoptotic Role of Telomerase in Pheochromocytoma Cells
Journal of Biological Chemistry·1999· 248 citedOpen Access
Altered Calcium Homeostasis and Mitochondrial Dysfunction in Cortical Synaptic Compartments of Presenilin‐1 Mutant Mice
Journal of Neurochemistry·1999· 157 cited
Amyloid β-peptide induces apoptosis-related events in synapses and dendrites
Brain Research·1998· 256 cited
Cryopreservation of rat cortical synaptosomes and analysis of glucose and glutamate transporter activities, and mitochondrial function
Brain Research Protocols·1998· 16 cited
Evidence for Synaptic Apoptosis
Experimental Neurology·1998· 341 cited
Bcl‐2 Protects Isolated Plasma and Mitochondrial Membranes Against Lipid Peroxidation Induced by Hydrogen Peroxide and Amyloid β‐Peptide
Journal of Neurochemistry·1998· 189 cited
17?-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid ?-peptide and iron
Journal of Neuroscience Research·1997· 165 cited
Aβ25–35 induces rapid lysis of red blood cells: contrast with Aβ1–42 and examination of underlying mechanisms
Brain Research·1997· 124 cited
Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal
Journal of Neurochemistry·1997· 439 citedOpen Access
4‐Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake
Journal of Neurochemistry·1997· 189 cited
Increased Activity‐Regulating and Neuroprotective Efficacy of α‐Secretase‐Derived Secreted Amyloid Precursor Protein Conferred by a C‐Terminal Heparin‐Binding Domain
Journal of Neurochemistry·1996· 392 cited
Amyloid β-peptide alters thrombin-induced calcium responses in cultured human neural cells
Amyloid·1996· 14 cited
The advantageous use of hypoxic tumour cells in cancer therapy: Identical chemosensitization by metronidazole and misonidazole at moderately elevated temperatures
International Journal of Hyperthermia·1995· 6 cited
Chapter 10 Calcium, Free Radicals, and Excitotoxic Neuronal Death in Primary Cell Culture
Methods in cell biology·1995· 335 cited
Protein kinase C inhibitor as a potent inhibitor of accelerated repopulation during radiotherapy: <i>I. growth inhibitory, cytotoxic, and indirect radiosensitizing effects of a staurosporine derivative (UCN‐01) in vitro</i>
Radiation Oncology Investigations·1995· 2 cited
Neurotrophin-4/5 protects hippocampal and cortical neurons against energy deprivation- and excitatory amino acid-induced injury
Brain Research·1994· 56 cited
Interaction between adriamycin cytotoxicity and hyperthermia: growth-phase-dependent thermal sensitization
International Journal of Hyperthermia·1994· 22 cited
INTRA-TUMOR HETEROGENEITY AND RADIORESISTANCE
Elsevier eBooks·1991
SENSITIVITY DIFFERENCES TO CIS-PLATIN BETWEEN PRIMARY TUMOR CELLS AND TUMOR CELLS RECURRENT AFTER IRRADIATION
Elsevier eBooks·1991
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Frequent Co-authors

Mark P. Mattson(10), Jeffrey N. Keller(4), Mark P. Mattson(4), Robert J. Mark(3), M. Urano(3), R. Reynolds(3), Ariane Germeyer(2), Georg Waeg(2), Katsutoshi Furukawa(2), Weiming Fu(2), D. Allan Butterfield(2), Hiroshi Maezawa(2), Zheng Pang(1), James W. Geddes(1), Bryce L. Sopher(1), Russell E. Rydel(1), Dao G. Pham(1), George M. Martin(1), Michael Fox(1), Steven W. Barger(1)