Andrea Gohlke

AstraZeneca (Brazil) — Brazil

Biochemistry, Genetics and Molecular Biology · Life Sciences

12h-index879citations38works4.62yr avg

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Research Topics

Lipid Membrane Structure and Behavior(11), Protein Kinase Regulation and GTPase Signaling(7), Cellular transport and secretion(5), Alzheimer's disease research and treatments(4), Computational Drug Discovery Methods(4)

Publications38 total

CBL ubiquitin ligase targets translation as a degrader E3

Chemical Science·2025Open Access

Optimization and Chemoproteomic Profiling of a Selective, Covalent Bfl-1-Targeting Cellular Tool

Journal of Medicinal Chemistry·2025

Structural and Molecular Insight into the PWWP1 Domain of NSD2 from the Discovery of Novel Binders Via DNA-Encoded Library Screening

ACS Medicinal Chemistry Letters·2025Open Access

Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders

1 cited

ACS Medicinal Chemistry Letters·2025· 1 cited

Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras

5 cited

Journal of Medicinal Chemistry·2025· 5 cited

Structure-Based Discovery of a Series of Covalent, Orally Bioavailable, and Selective BFL1 Inhibitors

3 cited

Journal of Medicinal Chemistry·2024· 3 cited

High throughput application of the NanoBiT Biochemical Assay for the discovery of selective inhibitors of the interaction of PI3K-p110α with KRAS

3 cited

SLAS DISCOVERY·2024· 3 citedOpen Access

Reversible Small Molecule pan-Ras Inhibitors Display Tunable Affinity for the Active and Inactive forms of Ras.

2024Open Access

Reversible Small Molecule pan-Ras Inhibitors Display Tunable Affinity for the Active and Inactive forms of Ras.

2024Open Access

Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors

7 cited

Journal of Medicinal Chemistry·2024· 7 citedOpen Access

Fragment-Based Discovery of Novel MUS81 Inhibitors

7 cited

ACS Medicinal Chemistry Letters·2024· 7 citedOpen Access

Identification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen

17 cited

ACS Medicinal Chemistry Letters·2024· 17 citedOpen Access

Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches

11 cited

Journal of Medicinal Chemistry·2024· 11 citedOpen Access

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors

10 cited

Journal of Medicinal Chemistry·2024· 10 citedOpen Access

Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity

12 cited

ACS Medicinal Chemistry Letters·2023· 12 citedOpen Access

Calmodulin extracts the ras family protein rala from lipid bilayers by engagement with two membrane-targeting motifs

1 cited

Biophysical Journal·2023· 1 citedOpen Access

Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex

3 cited

Biochemistry·2022· 3 citedOpen Access

Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling

22 cited

Journal of Medicinal Chemistry·2022· 22 citedOpen Access

Fragment screening at AstraZeneca: developing the next generation biophysics fragment set

12 cited

RSC Medicinal Chemistry·2022· 12 citedOpen Access

PINK1 drives production of mtDNA-containing extracellular vesicles to promote invasiveness

131 cited

The Journal of Cell Biology·2021· 131 citedOpen Access

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Frequent Co-authors

Alexander G. Milbradt(9), Angelo Pugliese(7), Justin Bower(7), Ulf Börjesson(7), Roland Winter(6), Charles Parry(6), Martin J. Drysdale(6), Heather J. McKinnon(6), Christopher H. Gray(5), Jennifer Konczal(5), Mokdad Mezna(5), Duncan McArthur(5), Simon C. C. Lucas(5), Mark J. Bostock(5), Frédéric Pincet(4), Alexander W. Schüttelkopf(4), Gillian Goodwin(4), David Hargreaves(4), Olaf Kinzel(4), Michelle L. Lamb(4)