Thomas Holm Pedersen

Aarhus University — Denmark

Biochemistry, Genetics and Molecular Biology · Life Sciences

25h-index2.5kcitations88works3.32yr avg
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Research Topics

Ion channel regulation and function(36), Muscle activation and electromyography studies(22), Cardiac electrophysiology and arrhythmias(18), Neuroscience and Neural Engineering(15), Cardiovascular and exercise physiology(8)

Publications88 total

The Neuromuscular Junction: A Shared Vulnerability in Aging and Disease
Journal of Neuroscience·2025
Chill-tolerant <i>Drosophila</i> species maintain electrogenic muscle membrane potential to resist cold-induced depolarization
Journal of Experimental Biology·2025
Chill tolerant <i>Drosophila</i> species maintain electrogenic muscle membrane potential to resist cold-induced depolarization
2025· 1 citedOpen Access
Neuromuscular transmission deficits in patients with <scp>CMT</scp> and <scp>ClC</scp>‐1 inhibition in <scp>CMT</scp> animal models
Annals of Clinical and Translational Neurology·2024· 3 citedOpen Access
Safety, Pharmacokinetics, and Pharmacodynamics of a First‐in‐Class <scp>ClC</scp>‐1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial
Clinical Pharmacology & Therapeutics·2024· 3 citedOpen Access
ClC-1 Inhibition as a Mechanism for Accelerating Skeletal Muscle Recovery After Neuromuscular Block in Rats
Nature Communications·2024· 3 citedOpen Access
103P NMD670, a first-in-class skeletal muscle ClC-1 Inhibitor in Charcot-Marie-Tooth disease: the SYNAPSE-CMT phase 2 study
Neuromuscular Disorders·2024· 1 cited
238P NMD670, a first-in-class skeletal muscle ClC-1 Inhibitor in myasthenia gravis: the SYNAPSE-MG dose-finding study
Neuromuscular Disorders·2024
ClC-1 Inhibition as a Novel Mechanism for Accelerating Recovery of Skeletal Muscle Function After Neuromuscular Block in an Experimental Rat Model
2024Open Access
The ClC-1 chloride channel inhibitor NMD670 improves skeletal muscle function in rat models and patients with myasthenia gravis
Science Translational Medicine·2024· 24 cited
SAFETY, PHARMACOKINETICS, AND PHARMACODYNAMICS OF A CLC-1 INHIBITOR - A FIRST-IN-CLASS COMPOUND THAT ENHANCES MUSCLE EXCITABILITY: A PHASE I, SINGLE- AND MULTIPLE-ASCENDING DOSE STUDY
2024· 1 citedOpen Access
Role of recovery of acetylcholine release in compromised neuromuscular junction function
Neuromuscular Disorders·2024· 4 cited
P272 NMD670, a novel first-in-class muscle ClC-1 inhibitor, improves symptoms of myasthenia gravis: a randomized, single-dose, double-blind, placebo-controlled study
Neuromuscular Disorders·2023· 1 cited
N°356 - Muscle velocity recovery cycles as pharmacodynamic biomarker in a first-in-human trial of a first-in-class chloride channel 1 inhibitor: A randomized, double-blind, placebo-controlled, cross-over study in healthy subjects and patients with myasthenia grav
Clinical Neurophysiology·2023
Six weeks of high-load resistance and low-load blood flow restricted training increase Na/K-ATPase sub-units α2 and β1 equally, but does not alter ClC-1 abundance in untrained human skeletal muscle
Journal of Muscle Research and Cell Motility·2023· 3 cited
Myopathy as a cause of Long COVID fatigue: Evidence from quantitative and single fiber EMG and muscle histopathology
Clinical Neurophysiology·2023· 24 citedOpen Access
Heavy-load and low-load blood flow restricted resistance training increases Na/K-ATPase subunit but not ClC-1 expression in untrained human skeletal muscle
Research Square (Research Square)·2022Open Access
Myopathy as a cause of fatigue in long‐term <scp>post‐COVID</scp>‐19 symptoms: Evidence of skeletal muscle histopathology
European Journal of Neurology·2022· 110 citedOpen Access
Alterations in fast‐twitch muscle membrane conductance regulation do not explain decreased muscle function of <scp>SOD1<sup>G93A</sup></scp> rats
Muscle & Nerve·2021· 1 cited
Reply to “Maybe myopathic EMG but not myopathy” and to “Exclude differentials before attributing post-COVID fatigue to myopathy”
Clinical Neurophysiology·2021
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Frequent Co-authors

Ole Bækgaard Nielsen(30), Frank Vincenzo de Paoli(14), Anders Riisager(9), Martin Broch‐Lips(8), Christopher Huang(7), Hatice Tankişi(7), Martin Skov(7), Johannes Overgaard(6), Thomas Harbo(5), Henning Andersen(5), James A. Fraser(4), Jane Agergaard(4), Lars Østergaard(4), Anders Findsen(4), Jeppe Seamus Bayley(4), Kristian Overgaard(4), Torben Clausen(4), W A Macdonald(3), Iman S. Gurung(3), Eva Kildall Hejbøl(2)