Larry M. C. Chow

Hong Kong Polytechnic University — Hong Kong

Medicine · Health Sciences

29h-index2.7kcitations88works2.02yr avg
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Research Topics

Drug Transport and Resistance Mechanisms(27), Research on Leishmaniasis Studies(15), HIV/AIDS drug development and treatment(12), Natural product bioactivities and synthesis(10), Synthesis and biological activity(8)

Publications88 total

Tetrandrine regulates NAADP-mediated calcium signaling through a LIMP-2-dependent and sphingosine-mediated mechanism
Nature Communications·2025· 1 citedOpen Access
A Targeted and Protease-Activated Genetically Encoded Melittin-Containing Particle for the Treatment of Cutaneous and Visceral Leishmaniasis
ACS Applied Materials & Interfaces·2024· 2 citedOpen Access
Chemical Modification of Cytochrome C for Acid-Responsive Intracellular Apoptotic Protein Delivery for Cancer Eradication
Pharmaceutics·2024· 1 citedOpen Access
Fexinidazole optimization: enhancing anti-leishmanial profile, metabolic stability and hERG safety
RSC Medicinal Chemistry·2024· 4 citedOpen Access
Identification of Binding Sites in the Nucleotide-Binding Domain of P-Glycoprotein for a Potent and Nontoxic Modulator, the Amine-Containing Monomeric Flavonoid <b>FM04</b>
Journal of Medicinal Chemistry·2023· 5 citedOpen Access
Supplementary Data from Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
2023Open Access
Data from Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
2023Open Access
Data from Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
2023Open Access
Supplementary Data from Disruption of SND1–MTDH Interaction by a High Affinity Peptide Results in SND1 Degradation and Cytotoxicity to Breast Cancer Cells &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
2023Open Access
In Vivo Reversal of P-Glycoprotein-Mediated Drug Resistance in a Breast Cancer Xenograft and in Leukemia Models Using a Novel, Potent, and Nontoxic Epicatechin EC31
International Journal of Molecular Sciences·2023· 14 citedOpen Access
Discovery of a Flavonoid FM04 as a Potent Inhibitor to Reverse P-Glycoprotein-Mediated Drug Resistance in Xenografts and Improve Oral Bioavailability of Paclitaxel
International Journal of Molecular Sciences·2022· 12 citedOpen Access
Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography
Pharmaceutics·2022· 9 citedOpen Access
Characterization of a Potent, Selective, and Safe Inhibitor, Ac15(Az8)2, in Reversing Multidrug Resistance Mediated by Breast Cancer Resistance Protein (BCRP/ABCG2)
International Journal of Molecular Sciences·2022· 9 citedOpen Access
Mechanical characterization of spider silk inspired peptide-containing hybrids
Materials & Design·2022· 12 citedOpen Access
Flavonoid Monomers as Potent, Nontoxic, and Selective Modulators of the Breast Cancer Resistance Protein (ABCG2)
Journal of Medicinal Chemistry·2021· 13 citedOpen Access
Synthesis and evaluation of stereoisomers of methylated catechin and epigallocatechin derivatives on modulating P-glycoprotein-mediated multidrug resistance in cancers
European Journal of Medicinal Chemistry·2021· 18 citedOpen Access
ATP-binding cassette (ABC) transporter proteins, multidrug resistance, and novel flavonoid dimers as potent, nontoxic, and selective inhibitors
Canadian Journal of Chemistry·2021· 2 cited
RUVBL1/2 Complex Regulates Pro-Inflammatory Responses in Macrophages via Regulating Histone H3K4 Trimethylation
Frontiers in Immunology·2021· 14 citedOpen Access
Natural Products Targeting Cancer Stem Cells: A Revisit
Current Medicinal Chemistry·2021· 11 cited
Amine-Linked Flavonoids as Agents against Cutaneous Leishmaniasis
Antimicrobial Agents and Chemotherapy·2021· 7 citedOpen Access
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Frequent Co-authors

Iris L. K. Wong(28), Tak Hang Chan(16), Kin‐Fai Chan(12), Tao Jiang(7), Yunzhe Zhao(6), Clare S. W. Yan(4), Zhen Liu(4), Xuesen Hu(4), Johnny Tang(4), Brendan A. Burkett(3), Sheng Wan(3), Shengbiao Wan(3), Hongzhe Sun(3), Xuezhen Zhu(3), Man Chun Law(3), Wenqin Sun(3), Chung Chui(3), Ivy Teo(3), Fung Lau(3), Raymond Wong(3)