Luc Bousset

Centre National de la Recherche Scientifique — France

Medicine · Health Sciences

54h-index12.3kcitations142works2.22yr avg
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Research Topics

Parkinson's Disease Mechanisms and Treatments(70), Alzheimer's disease research and treatments(41), Prion Diseases and Protein Misfolding(39), Neurological diseases and metabolism(32), Neurological disorders and treatments(19)

Publications142 total

Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
Nature·2025· 4 citedOpen Access
Structure of in-vivo formed alpha-synuclein fibrils purified from a M83+/- mouse brain injected with recombinant 1B fibrils
EMPIAR dataset·2025Open Access
RePo-SUDOE – A translational network for drug repurposing in the SUDOE space
2025Open Access
Perilipin 4 repetitive region forms amyloid fibrils promoted by a genetic expansion found in myopathy patients
2025Open Access
Imaging α-synuclein protein aggregation by CEST-MRI for monitoring of synucleinopathies
Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition·2024
Synthetic α-synuclein fibrils replicate in mice causing MSA-like pathology
2024· 5 citedOpen Access
Aptamer binding footprints discriminate α-synuclein fibrillar polymorphs from different synucleinopathies
Nucleic Acids Research·2024· 3 citedOpen Access
Transmissible long-term neuroprotective and pro-cognitive effects of 1–42 beta-amyloid with A2T icelandic mutation in an Alzheimer’s disease mouse model
Molecular Psychiatry·2024· 8 citedOpen Access
Cryo-EM images of alpha-synuclein fibrils «1B» capable of seeding GCI in vivo
EMPIAR dataset·2024Open Access
Synapses do not facilitate prion-like transfer of alpha-synuclein: a quantitative study in reconstructed unidirectional neural networks
Cellular and Molecular Life Sciences·2023· 8 citedOpen Access
Long term worsening of amyloid pathology, cerebral function, and cognition after a single inoculation of beta-amyloid seeds with Osaka mutation
Acta Neuropathologica Communications·2023· 5 citedOpen Access
Functional and neuropathological changes induced by injection of distinct alpha-synuclein strains: A pilot study in non-human primates
Neurobiology of Disease·2023· 15 citedOpen Access
Long term worsening of Alzheimer pathology and clinical outcome by a single inoculation of mutated beta-amyloid seeds
2022· 1 citedOpen Access
α-Synuclein Fibril, Ribbon and Fibril-91 Amyloid Polymorphs Generation for Structural Studies
Methods in molecular biology·2022· 4 citedOpen Access
Propagation of Distinct α-Synuclein Strains Within Human Reconstructed Neuronal Network and Associated Neuronal Dysfunctions
Methods in molecular biology·2022· 4 cited
<i>C9ORF72</i>-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons
Life Science Alliance·2022· 10 citedOpen Access
Neurons with Cat’s Eyes: A Synthetic Strain of α-Synuclein Fibrils Seeding Neuronal Intranuclear Inclusions
Biomolecules·2022· 12 citedOpen Access
<i>C9orf72</i> -derived poly-GA DPRs undergo endocytic uptake in iNPC-derived astrocytes and spread to motor neurons
2021Open Access
Quantitative study of alpha-synuclein prion-like spreading in fully oriented reconstructed neural networks reveals non-synaptic dissemination of seeding aggregates
2021· 1 citedOpen Access
LGALS3 (galectin 3) mediates an unconventional secretion of SNCA/α-synuclein in response to lysosomal membrane damage by the autophagic-lysosomal pathway in human midbrain dopamine neurons
Autophagy·2021· 67 citedOpen Access
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Frequent Co-authors

Ronald Melki(47), Laura Pieri(7), Karine Madiona(6), Anja Böckmann(6), Beat H. Meier(6), Birgit Habenstein(5), Alexis Fenyi(4), Nolwen L. Rey(4), Patrik Brundin(4), Wouter Peelaerts(3), Veerle Baekelandt(3), Julia Gath(3), Yannick Sourigues(3), Michel Brahic(3), Amulya Nidhi Shrivastava(3), Virginie Redeker(3), Marianne Renner(3), Antoine Triller(3), Anke Van der Perren(2), Chris Van den Haute(2)