Gopinath Krishnan

University of Massachusetts Chan Medical School — United States

Medicine · Health Sciences

14h-index953citations32works2.72yr avg
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Research Topics

Amyotrophic Lateral Sclerosis Research(21), Neurogenetic and Muscular Disorders Research(12), Genetic Neurodegenerative Diseases(6), Neuroscience and Neuropharmacology Research(3), Cannabis and Cannabinoid Research(3)

Publications32 total

Blocking RAN translation without altering repeat RNAs rescues <i>C9ORF72</i> -related ALS and FTD phenotypes
Science·2026· 1 cited
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Cell·2026Open Access
Nemo-like kinase disrupts nuclear import and drives TDP43 mislocalization in ALS
Journal of Clinical Investigation·2025Open Access
Poly-GR repeats associated with ALS/FTD gene <i>C9ORF72</i> impair translation elongation and induce a ribotoxic stress response in neurons
Science Signaling·2024· 11 citedOpen Access
The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD
Cell Reports·2024Open Access
Traumatic injury causes selective degeneration and TDP-43 mislocalization in human iPSC-derived <i>C9orf72</i> -associated ALS/FTD motor neurons
2024· 7 citedOpen Access
Referee report. For: Differential physical interactions of wild-type and S59L mutant CHCHD10 with mitochondrial proteases [version 1; peer review: 1 approved with reservations, 1 not approved]
Faculty of 1000 Research Ltd·2024Open Access
Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons
eLife·2023· 13 citedOpen Access
Author response: Translation of dipeptide repeat proteins in C9ORF72 ALS/FTD through unique and redundant AUG initiation codons
2023Open Access
Downregulation of Hsp90 and the antimicrobial peptide Mtk suppresses poly(GR)-induced neurotoxicity in C9ORF72-ALS/FTD
Neuron·2023· 26 citedOpen Access
PIKFYVE inhibition mitigates disease in models of diverse forms of ALS
Cell·2023· 91 citedOpen Access
The enhanced association between mutant CHMP2B and spastin is a novel pathological link between frontotemporal dementia and hereditary spastic paraplegias
Acta Neuropathologica Communications·2022· 4 citedOpen Access
CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro
Nature Communications·2022· 62 citedOpen Access
Translation of dipeptide repeat proteins in <i>C9ORF72</i> -ALS/FTD through unique and redundant AUG initiation codons
2022· 1 citedOpen Access
Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD
Nature Communications·2022· 52 citedOpen Access
CRISPR/Cas9-Mediated Excision of ALS/FTD-Causing Hexanucleotide Repeat Expansion in <i>C9ORF72</i> rescues major disease mechanisms <i>in vivo</i> and <i>in vitro</i>
2022· 1 citedOpen Access
A C. elegans model of C9orf72-associated ALS/FTD uncovers a conserved role for eIF2D in RAN translation
Nature Communications·2021· 49 citedOpen Access
Altered MICOS Morphology and Mitochondrial Ion Homeostasis Contribute to Poly(GR) Toxicity Associated with C9-ALS/FTD
Cell Reports·2020· 46 citedOpen Access
CRISPR deletion of the C9ORF72 promoter in ALS/FTD patient motor neurons abolishes production of dipeptide repeat proteins and rescues neurodegeneration
Acta Neuropathologica·2020· 36 citedOpen Access
Transcription elongation factor AFF2/FMR2 regulates expression of expanded GGGGCC repeat-containing C9ORF72 allele in ALS/FTD
Nature Communications·2019· 51 citedOpen Access
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Frequent Co-authors

Fen‐Biao Gao(20), Nivedita Chatterjee(8), Yuanzheng Gu(7), Soojin Lee(5), Sandra Almeida(4), Tania F. Gendron(4), Mark W. Kankel(4), Yoshifumi Sonobe(4), Raymond P. Roos(4), Paschalis Kratsios(4), Deborah Y. Kwon(4), Gabriel Linares(3), Manuel Santana(3), Leonard Petrucelli(3), Robert H. Brown(3), So Yoen Choi(2), S. Ali(2), Yunsun Eoh(2), Stacee Mendonca(2), Sarah Hong(2)