Ivan Hirsch

Charles University — Czech Republic

Immunology and Microbiology · Life Sciences

32h-index3.3kcitations151works0.52yr avg
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Research Topics

HIV Research and Treatment(51), Immune Cell Function and Interaction(28), HIV/AIDS drug development and treatment(25), Cytomegalovirus and herpesvirus research(21), Herpesvirus Infections and Treatments(18)

Publications151 total

STING agonists trigger monocyte death via apoptosis, pyroptosis, caspase-8 activation and mitochondrial dysfunction
Cell Death Discovery·2025· 1 citedOpen Access
UBE2O, a host ubiquitin-conjugating enzyme, is a key regulator of hepatitis B virus maturation and egress
Journal of Biological Chemistry·2025Open Access
Prophylactic vaccines against cancers of non-infectious origin: a dream or a real possibility?
Central European Journal of Public Health·2021· 2 citedOpen Access
ATM-Dependent Phosphorylation of Hepatitis B Core Protein in Response to Genotoxic Stress
Viruses·2021· 8 citedOpen Access
TLR4-Mediated Recognition of Mouse Polyomavirus Promotes Cancer-Associated Fibroblast-Like Phenotype and Cell Invasiveness
Cancers·2021· 9 citedOpen Access
Hepatitis B Core Protein Is Post-Translationally Modified through K29-Linked Ubiquitination
Cells·2020· 18 citedOpen Access
Toll-like receptor dual-acting agonists are potent inducers of PBMC-produced cytokines that inhibit hepatitis B virus production in primary human hepatocytes
Scientific Reports·2020· 26 citedOpen Access
Hepatitis B Virus Evasion From Cyclic Guanosine Monophosphate–Adenosine Monophosphate Synthase Sensing in Human Hepatocytes
Hepatology·2018· 92 citedOpen Access
Expression of TIM-3 on Plasmacytoid Dendritic Cells as a Predictive Biomarker of Decline in HIV-1 RNA Level during ART
Viruses·2018· 6 citedOpen Access
The MEK1/2-ERK Pathway Inhibits Type I IFN Production in Plasmacytoid Dendritic Cells
Frontiers in Immunology·2018· 27 citedOpen Access
PRMT5: A novel regulator of Hepatitis B virus replication and an arginine methylase of HBV core
PLoS ONE·2017· 49 citedOpen Access
Virus Restriction and Adaptation during Latent and Chronic Infection
2017
Cross Talk between Inhibitory Immunoreceptor Tyrosine-Based Activation Motif-Signaling and Toll-Like Receptor Pathways in Macrophages and Dendritic Cells
Frontiers in Immunology·2017· 46 citedOpen Access
P-C23 Spleen tyrosine kinase (Syk) controls IFN-α production inhibited in plasmacytoid dendritic cells by surface glycoproteins of HIV, HBV and HCV
JAIDS Journal of Acquired Immune Deficiency Syndromes·2017Open Access
P-D1 Transient stimulation of cells harboring latent proviruses contributes to the methylation of the HIV-1 promoter
JAIDS Journal of Acquired Immune Deficiency Syndromes·2017
Crosstalk between inhibitory ITAM signaling and TLR pathways in macrophages and dendritic cells
Frontiers in Immunology·2017Open Access
Dual Role of the Tyrosine Kinase Syk in Regulation of Toll-Like Receptor Signaling in Plasmacytoid Dendritic Cells
PLoS ONE·2016· 32 citedOpen Access
Development of 5‘ LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals
Clinical Epigenetics·2016· 62 citedOpen Access
Additional file 3: Figure S3. of Development of 5‘ LTR DNA methylation of latent HIV-1 provirus in cell line models and in long-term-infected individuals
Figshare·2016Open Access
Full but impaired activation of innate immunity effectors and virus-specific T cells during CMV and EBV disease following cord blood transplantation
Bone Marrow Transplantation·2015· 1 cited
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Frequent Co-authors

Daniel Olive(11), Françoise Gondois‐Rey(9), Jean‐Claude Chermann(6), V. Vonka(6), Jan Weber(6), Beda Břicháček(6), Kateřina Trejbalová(5), Jiřı́ Hejnar(5), Thomas F. Baumert(5), Angélique Biancotto(5), Jacques A. Nunès(5), Růžena Stránská(5), Jana Blažková(4), Jonathan Florentin(4), Leonid Margolis(4), Jean‐Charles Grivel(4), Bruno Spire(4), Besma Aouar(4), V. Janovec(4), Carine Van Lint(3)