Suk See De Ravin

National Institutes of Health — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

44h-index8.0kcitations151works6.82yr avg
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Research Topics

Virus-based gene therapy research(48), CRISPR and Genetic Engineering(42), Neutrophil, Myeloperoxidase and Oxidative Mechanisms(37), CAR-T cell therapy research(36), Immunodeficiency and Autoimmune Disorders(28)

Publications151 total

Sensitive and unbiased genome-wide profiling of base-editor-induced off-target activity using CHANGE-seq-BE
Nature Biotechnology·2026· 2 citedOpen Access
Clinical Characteristics, Management, and Hematopoietic Cell Transplantation of Patients with TLR8 Gain-of-Function
Blood Advances·2025Open Access
Prime Editing for p47 <sup>phox</sup> -Deficient Chronic Granulomatous Disease
New England Journal of Medicine·2025· 1 cited
First in human prime edited autologous hematopoietic stem cell therapy for the treatment of p47phox CGD: Initial results of PRIME-0101
Blood·2025Open Access
Lymphedema in patients with X-linked severe combined immunodeficiency
Journal of Allergy and Clinical Immunology Global·2025Open Access
Long-Term Safety and Efficacy of Gene Therapy for Adenosine Deaminase Deficiency
New England Journal of Medicine·2025· 5 cited
Further Personalizing Medicine in Immune Disorders: Genomic Findings and Hematopoietic Cell Transplantation Survival
Transplantation·2025
A novel frameshift mutation in Phosphoinositide 3-kinase regulatory subunit 1 ( <i>PIK3R1</i> ) causes immunodeficiency and Amyotrophic Lateral Sclerosis (ALS)
2025Open Access
A Novel Dominant Negative Variant in IL2RG Gene that Failed to Be Corrected by Lentiviral Gene Therapy
Journal of Human Immunity·2025Open Access
Norovirus Infection at the NIH Clinical Center from 2010 to 2023: A Comparative Analysis of Acute vs. Chronic Norovirus Infection with a Focus on Inborn Errors of Immunity
Journal of Human Immunity·2025Open Access
Custom CRISPR–Cas9 PAM variants via scalable engineering and machine learning
Nature·2025· 38 citedOpen Access
Norovirus infection at the NIH Clinical Center from 2010-2023: A comparative analysis of acute vs chronic norovirus infection with a focus on inborn errors of immunity
Journal of Allergy and Clinical Immunology·2025
Multiomics dissection of human RAG deficiency reveals distinctive patterns of immune dysregulation but a common inflammatory signature
Science Immunology·2025· 9 citedOpen Access
High-fidelity PAMless base editing of hematopoietic stem cells to treat chronic granulomatous disease
Science Translational Medicine·2024· 15 citedOpen Access
Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Cell stem cell·2024· 5 citedOpen Access
Impact of CRISPR/HDR editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
Cell stem cell·2024· 20 citedOpen Access
Exonic knockout and knockin gene editing in hematopoietic stem and progenitor cells rescues RAG1 immunodeficiency
Science Translational Medicine·2024· 20 citedOpen Access
Impact of CRISPR/HDR-editing versus lentiviral transduction on long-term engraftment and clonal dynamics of HSPCs in rhesus macaques
2023· 1 citedOpen Access
Clinical Characteristics, Management, and Allogeneic Hematopoietic Cell Transplantation of Patients with Toll-like Receptor 8 Gain-of-Function Mutations
Blood·2023· 2 cited
Prime Editing Efficiently and Precisely Corrects Causative Mutation in Chronic Granulomatous Disease, Restoring Myeloid Function: Toward Development of a Prime Edited Autologous Hematopoietic Stem Cell Therapy
Blood·2023· 11 cited
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Frequent Co-authors

Harry L. Malech(45), Douglas B. Kuhns(16), Steven M. Holland(15), Uimook Choi(13), Gülbû Uzel(10), Elizabeth M. Kang(10), Xiaolin Wu(10), John I. Gallin(9), Luigi D. Notarangelo(9), Colin L. Sweeney(9), Kol A. Zarember(8), Christa S. Zerbe(8), Theo Heller(6), Beatriz E. Marciano(6), Narda Theobald(6), Jennifer M. Puck(6), Sherry Koontz(6), Alexandra F. Freeman(5), Ling Su(5), Janet Lee(5)