Martin Augustin

ProterixBio (United States) — United States

Medicine · Health Sciences

28h-index2.9kcitations70works0.02yr avg
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Research Topics

Chronic Lymphocytic Leukemia Research(10), CRISPR and Genetic Engineering(7), PI3K/AKT/mTOR signaling in cancer(7), Biochemical and Molecular Research(6), Muscle Physiology and Disorders(4)

Publications70 total

PI3Kδ is selectively inhibited by roginolisib through stabilizing of the C-terminal helix kα12
2026Open Access
Structures, functions and adaptations of the human LINE-1 ORF2 protein
Nature·2023· 109 citedOpen Access
Biophysical and structural characterization of the impacts of MET phosphorylation on tepotinib binding
Journal of Biological Chemistry·2023· 4 citedOpen Access
Abstract 6179: Comparative study of Polθ helicase and polymerase inhibitor biochemical and cellular potency
Cancer Research·2023
Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry
Bioorganic & Medicinal Chemistry·2021· 42 citedOpen Access
Discovery of a new series of PI3K-δ inhibitors from Virtual Screening
Bioorganic & Medicinal Chemistry Letters·2021· 4 citedOpen Access
Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors
ACS Medicinal Chemistry Letters·2020· 15 citedOpen Access
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction
Bioorganic & Medicinal Chemistry·2020· 26 citedOpen Access
Corrigendum to “Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow” [Bioorg. Med. Chem. Lett. 29 (2019) 2575–2580]
Bioorganic & Medicinal Chemistry Letters·2020· 1 cited
Combined Peptide and Small-Molecule Approach toward Nonacidic THIQ Inhibitors of the KEAP1/NRF2 Interaction
ACS Medicinal Chemistry Letters·2020· 28 citedOpen Access
Strategic Incorporation of Polarity in Heme-Displacing Inhibitors of Indoleamine-2,3-dioxygenase-1 (IDO1)
ACS Medicinal Chemistry Letters·2020· 32 citedOpen Access
Discovery of sulfonamides and 9-oxo-2,8-diazaspiro[5,5]undecane-2-carboxamides as human kynurenine aminotransferase 2 (KAT2) inhibitors
Bioorganic & Medicinal Chemistry Letters·2020· 4 citedOpen Access
Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors
Bioorganic & Medicinal Chemistry Letters·2019· 11 citedOpen Access
Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow
Bioorganic & Medicinal Chemistry Letters·2019· 18 citedOpen Access
Design and Evaluation of Highly Selective Human Immunoproteasome Inhibitors Reveal a Compensatory Process That Preserves Immune Cell Viability
Journal of Medicinal Chemistry·2019· 34 cited
Discovery of a Potent, Orally Bioavailable PI4KIIIβ Inhibitor (UCB9608) Able To Significantly Prolong Allogeneic Organ Engraftment <i>in Vivo</i>
Journal of Medicinal Chemistry·2018· 20 citedOpen Access
Structures and mechanism of dipeptidyl peptidases 8 and 9, important players in cellular homeostasis and cancer
Proceedings of the National Academy of Sciences·2018· 82 citedOpen Access
Discovery of Selective Phosphodiesterase 1 Inhibitors with Memory Enhancing Properties
Journal of Medicinal Chemistry·2017· 55 citedOpen Access
Abstract 4800: Covalent Flt3-Cys828 inhibition represents a novel therapeutic approach for the treatment of Flt3-ITD and Flt3-D835 mutant acute myeloid leukemia
Cancer Research·2016· 4 cited
Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site
Acta Crystallographica Section D Structural Biology·2016· 19 citedOpen Access
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Frequent Co-authors

Stefan Steinbacher(12), Robert Huber(8), Dirk Korthaus(5), Sigrid Wattler(5), Stephan Krapp(5), Alfred Lammens(4), Michael Nehls(4), S. Gerhardt(4), Reinhard Sedlmeier(4), Meredeth A. McGowan(4), Xavier Fradera(4), Charles A. Lesburg(4), Harald Jockusch(4), Andreas Marquardt(3), Helmut Fuchs(3), Martin Hrabě de Angelis(3), Andreas Russ(3), Gabriele Stumm(3), Gabi Stumm(3), Joey L. Methot(3)