Stacy L. Springs

Massachusetts Institute of Technology — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

20h-index1.7kcitations79works2.42yr avg
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Research Topics

Viral Infectious Diseases and Gene Expression in Insects(25), Virus-based gene therapy research(16), Protein purification and stability(9), CAR-T cell therapy research(9), CRISPR and Genetic Engineering(7)

Publications79 total

Partial least-squares model adaptation by bootstrap resampling
Computers & Chemical Engineering·2026
Advanced Characterization Methods for Crystals of an Extraordinary Material
arXiv (Cornell University)·2025Open Access
Continuous Production of Recombinant Adeno-Associated Virus in the Insect Cell/Baculovirus Expression Vector System
2025Open Access
Selective Enrichment of Full Capsids of Adeno-Associated Virus
ACS Nano·2025· 1 cited
A phase diagram for crystallization of a complex macromolecular assembly
Chemical Engineering Science·2025
Rapid Universal Detection of High‐Risk and Low‐Abundance Microbial Contaminations in CAR‐T Cell Therapy (Small Methods 8/2025)
Small Methods·2025Open Access
Chemical sensing as a utility using parallel, distributed swept source Raman spectroscopy
Optics Express·2025Open Access
An Integrated Experimental and Modeling Approach for Crystallization of Complex Biotherapeutics
Crystal Growth & Design·2025· 2 citedOpen Access
A sensitive sample preparation pipeline for adventitious virus detection using Oxford Nanopore sequencing
Molecular Therapy — Methods & Clinical Development·2025Open Access
Rapid Universal Detection of High‐Risk and Low‐Abundance Microbial Contaminations in CAR‐T Cell Therapy
Small Methods·2025· 1 citedOpen Access
Perfusion‐Based Production of rAAV via an Intensified Transient Transfection Process
Biotechnology and Bioengineering·2025· 2 citedOpen Access
Machine learning aided UV absorbance spectroscopy for microbial contamination in cell therapy products
Scientific Reports·2025· 1 citedOpen Access
A Phase Diagram for Crystallization of a Complex Macromolecular Assembly
arXiv (Cornell University)·2025· 1 citedOpen Access
Extracellular viral microRNAs as biomarkers of virus infection in human cells
Molecular Therapy — Nucleic Acids·2024· 2 citedOpen Access
An Integrated Experimental and Modeling Approach for Crystallization of\n Complex Biotherapeutics
arXiv (Cornell University)·2024Open Access
Selective Enrichment of Full AAV Capsids
arXiv (Cornell University)·2024Open Access
Continuous Production of rAAV via an Intensified Transient Transfection Process
2024· 1 citedOpen Access
Machine learning aided UV Absorbance Spectroscopy for microbial contamination in cell therapy products
2024Open Access
Multidose transient transfection of human embryonic kidney 293 cells modulates recombinant adeno‐associated virus2/5 Rep protein expression and influences the enrichment fraction of filled capsids
Biotechnology and Bioengineering·2024· 7 citedOpen Access
The state of technological advancement to address challenges in the manufacture of rAAV gene therapies
Biotechnology Advances·2024· 18 cited
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Frequent Co-authors

Jacqueline M. Wolfrum(21), Paul W. Barone(19), Anthony J. Sinskey(17), Richard D. Braatz(14), Moo Sun Hong(9), Caleb Neufeld(9), Jonathan L. Sessler(7), Tam Nguyen(6), Donovan Guttieres(5), Georgios Katsikis(5), Sha Sha(5), Andrew J. Maloney(5), Xiaolin Wu(5), Retsef Levi(5), Prasanna Srinivasan(5), Rui Wen Ou(5), James C. Leung(4), Flora J. Keumurian(4), Scott R. Manalis(4), Cheryl Chan(4)