Tim I. Breugem

Erasmus MC — Netherlands

Medicine · Health Sciences

14h-index3.5kcitations25works5.02yr avg
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Research Topics

SARS-CoV-2 and COVID-19 Research(23), Respiratory viral infections research(9), COVID-19 Clinical Research Studies(8), Viral gastroenteritis research and epidemiology(7), Virus-based gene therapy research(5)

Publications25 total

Variable DPP4 expression in multiciliated cells of the human nasal epithelium as a determinant for MERS-CoV tropism
Proceedings of the National Academy of Sciences·2025· 7 citedOpen Access
Resistance to SARS-CoV-2 infection in camelid nasal organoids is associated with lack of ACE2 expression
npj Viruses·2024· 3 citedOpen Access
SARS-CoV-2 Omicron entry is type II transmembrane serine protease-mediated in human airway and intestinal organoid models
Journal of Virology·2023· 47 citedOpen Access
Correction for Mols et al., “Intestinal Tropism of a Betacoronavirus ( <i>Merbecovirus</i> ) in Nathusius’s Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host”
Journal of Virology·2023Open Access
Intestinal Tropism of a Betacoronavirus ( <i>Merbecovirus</i> ) in Nathusius’s Pipistrelle Bat ( <i>Pipistrellus nathusii</i> ), Its Natural Host
Journal of Virology·2023· 10 citedOpen Access
Antigenic cartography of SARS-CoV-2 reveals that Omicron BA.1 and BA.2 are antigenically distinct
Science Immunology·2022· 164 citedOpen Access
Omicron BA.1 and BA.2 are antigenically distinct SARS-CoV-2 variants
2022· 50 citedOpen Access
Divergent SARS-CoV-2 Omicron–reactive T and B cell responses in COVID-19 vaccine recipients
Science Immunology·2022· 433 citedOpen Access
SARS-CoV-2 Omicron efficiently infects human airway, but not alveolar epithelium
2022· 53 citedOpen Access
Divergent SARS CoV-2 Omicron-specific T- and B-cell responses in COVID-19 vaccine recipients
2021· 34 citedOpen Access
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
Nature Communications·2021· 97 citedOpen Access
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
2021· 13 citedOpen Access
Human organoid systems reveal <i>in vitro</i> correlates of fitness for SARS-CoV-2 B.1.1.7
2021· 12 citedOpen Access
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
eLife·2021· 101 citedOpen Access
Author response: Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
2021· 3 citedOpen Access
Human airway cells prevent SARS-CoV-2 multibasic cleavage site cell culture adaptation
2021· 12 citedOpen Access
SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site
eLife·2021· 153 citedOpen Access
Extended Shedding and Enhanced Fitness of the SARS-CoV-2 Variant of Concern B.1.1.7 in Human Organoid Systems
SSRN Electronic Journal·2021Open Access
Susceptibility of rabbits to SARS-CoV-2
Emerging Microbes & Infections·2020· 140 citedOpen Access
Author response: SARS-CoV-2 entry into human airway organoids is serine protease-mediated and facilitated by the multibasic cleavage site
2020Open Access
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Frequent Co-authors

Mart M. Lamers(25), Bart L. Haagmans(25), Anna Z. Mykytyn(23), Debby Schipper(21), Petra B. van den Doel(19), Samra Riesebosch(13), Marion Koopmans(11), Hans Clevers(8), Theo M. Bestebroer(8), Jelte van der Vaart(7), Corine H. GeurtsvanKessel(7), Joep Beumer(6), Kèvin Knoops(6), Peter J. Peters(6), Nathalie Gröen(5), Yiquan Wang(5), Douglas C. Wu(5), Nicholas C. Wu(5), Jingshu Zhang(5), Jens Puschhof(4)