Žiga Skok

University of Ljubljana — SI

Biochemistry, Genetics and Molecular Biology · Life Sciences

14h-index708citations24works2.52yr avg
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Research Topics

Cancer therapeutics and mechanisms(21), Bioactive Compounds and Antitumor Agents(10), Antibiotic Resistance in Bacteria(9), Synthesis and biological activity(5), Heat shock proteins research(4)

Publications24 total

Hiding in plain sight: Optimizing topoisomerase IIα inhibitors into Hsp90β selective binders
European Journal of Medicinal Chemistry·2024· 2 citedOpen Access
First dual inhibitors of human topoisomerase IIα and Hsp90 C-terminal domain inhibit the growth of Ewing sarcoma in vitro and in vivo
Bioorganic Chemistry·2024· 1 citedOpen Access
Improved N-phenylpyrrolamide inhibitors of DNA gyrase as antibacterial agents for high-priority bacterial strains
European Journal of Medicinal Chemistry·2024· 3 citedOpen Access
New <i>N</i>-phenylpyrrolamide inhibitors of DNA gyrase with improved antibacterial activity
RSC Advances·2024· 4 citedOpen Access
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate <i>Staphylococcus aureus</i>
Journal of Medicinal Chemistry·2023· 34 citedOpen Access
ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold
European Journal of Medicinal Chemistry·2023· 6 citedOpen Access
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against <i>Acinetobacter baumannii</i> and <i>Pseudomonas aeruginosa</i>
Journal of Medicinal Chemistry·2023· 51 citedOpen Access
Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores
Pharmaceuticals·2021· 9 citedOpen Access
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens
European Journal of Medicinal Chemistry·2021· 32 citedOpen Access
Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation
Pharmaceutics·2020· 15 citedOpen Access
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors
ACS Medicinal Chemistry Letters·2020· 49 citedOpen Access
Rational design of balanced dual-targeting antibiotics with limited resistance
PLoS Biology·2020· 41 citedOpen Access
Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors
Bioorganic Chemistry·2020· 17 cited
Cover Feature: Dual <i>Escherichia coli</i> DNA Gyrase A and B Inhibitors with Antibacterial Activity (ChemMedChem 3/2020)
ChemMedChem·2020Open Access
Second-Generation 4,5,6,7-Tetrahydrobenzo[ <i>d</i> ]Thiazoles as Novel DNA Gyrase Inhibitors
Future Medicinal Chemistry·2020· 13 citedOpen Access
Synthesis and evaluation of anticancer activity of new 9-acridinyl amino acid derivatives
RSC Medicinal Chemistry·2020· 22 citedOpen Access
Design, synthesis and biological evaluation of novel DNA gyrase inhibitors and their siderophore mimic conjugates
Bioorganic Chemistry·2019· 20 citedOpen Access
Dual <i>Escherichia coli</i> DNA Gyrase A and B Inhibitors with Antibacterial Activity
ChemMedChem·2019· 21 cited
Dual Inhibitors of Human DNA Topoisomerase II and Other Cancer-Related Targets
Journal of Medicinal Chemistry·2019· 201 citedOpen Access
Synthesis and biological evaluation of hybrid quinolone-based quaternary ammonium antibacterial agents
European Journal of Medicinal Chemistry·2019· 74 citedOpen Access
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Frequent Co-authors

Janez Ilaš(22), Tihomir Tomašič(20), Nace Zidar(19), D. Kikelj(17), Anamarija Zega(15), Lucíja Peterlin Mašič(15), Martina Durcik(11), Csaba Pál(11), Petra Szili(9), Cristina D. Cruz(8), Päivi Tammela(8), Gábor Draskovits(8), Ákos Nyerges(8), Davide Benedetto Tiz(5), Andrej Emanuel Cotman(4), Michaela Barančoková(4), Tamás Révész(4), Jaka Dernovšek(4), Julia E. A. Mundy(3), Anthony Maxwell(3)