Mirko M. Maksimainen

University of Oulu — Finland

Medicine · Health Sciences

15h-index909citations52works22.72yr avg
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Research Topics

PARP inhibition in cancer therapy(27), Toxin Mechanisms and Immunotoxins(17), Enzyme Production and Characterization(9), Enzyme Structure and Function(8), Calcium signaling and nucleotide metabolism(8)

Publications50 total

Optimization of 2,3-dihydrophthalazine-1,4-dione PARP inhibitor scaffold for nanomolar potency and specificity towards human PARP10
European Journal of Medicinal Chemistry·2025· 1 citedOpen Access
PARP15 catalytic domain in complex with OUL310
2025
Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target
Journal of Medicinal Chemistry·2024· 17 citedOpen Access
Oligomerization mediated by the D2 domain of DTX3L is critical for DTX3L‐PARP9 reading function of mono‐ADP‐ribosylated androgen receptor
Protein Science·2024· 10 citedOpen Access
Oligomerisation mediated by the D2 domain of DTX3L is critical for DTX3L-PARP9 reading function of mono-ADP-ribosylated androgen receptor
2023· 2 citedOpen Access
A Master of Science course on macromolecular X-ray crystallography resembling a realistic research project
2023Open Access
Discovery of 2-amide-3-methylester thiophenes that target SARS-CoV-2 Mac1 and repress coronavirus replication, validating Mac1 as an anti-viral target
2023· 5 citedOpen Access
[1,2,4]Triazolo[3,4- <i>b</i> ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes
Journal of Medicinal Chemistry·2023· 23 citedOpen Access
[1,2,4]Triazolo[3,4- <i>b</i> ]benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes
2022Open Access
Medicinal Chemistry Perspective on Targeting Mono-ADP-Ribosylating PARPs with Small Molecules
Journal of Medicinal Chemistry·2022· 34 citedOpen Access
Potent 2,3-dihydrophthalazine-1,4-dione derivatives as dual inhibitors for mono-ADP-ribosyltransferases PARP10 and PARP15
European Journal of Medicinal Chemistry·2022· 8 citedOpen Access
Preparation of screening assays for ADP-ribosyl readers and erasers using the GAP-tag as a binding probe
STAR Protocols·2022· 8 citedOpen Access
A molecular toolbox for ADP-ribosyl binding proteins
Cell Reports Methods·2021· 39 citedOpen Access
Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs
Bioorganic & Medicinal Chemistry·2021· 12 citedOpen Access
Cover Feature: Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10 (ChemistryOpen 10/2021)
ChemistryOpen·2021Open Access
Analogs of TIQ-A as inhibitors of human mono-ADP-ribosylating PARPs
2021Open Access
Evaluation of 3‐ and 4‐Phenoxybenzamides as Selective Inhibitors of the Mono‐ADP‐Ribosyltransferase PARP10
ChemistryOpen·2021· 14 citedOpen Access
Activation of PARP2/ARTD2 by DNA damage induces conformational changes relieving enzyme autoinhibition
Nature Communications·2021· 66 citedOpen Access
A molecular toolbox for ADP-ribosyl binding proteins
2021· 8 citedOpen Access
<i>IceBear</i>: an intuitive and versatile web application for research-data tracking from crystallization experiment to PDB deposition
Acta Crystallographica Section D Structural Biology·2021· 29 citedOpen Access
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Frequent Co-authors

L. Lehtiö(39), Albert Galera‐Prat(17), Sven T. Sowa(13), Juha Rouvinen(11), Sarah Wazir(10), Sudarshan Murthy(10), Ezeogo Obaji(8), Heli I. Alanen(7), Oriana Tabarrini(6), Bernhard Lüscher(6), Patricia Korn(6), Nina Hakulinen(5), Maria Giulia Nizi(5), Serena Massari(5), Yashwanth Ashok(5), Juho Alaviuhkola(5), Barbara E. Lippok(5), Juha P. Heiskanen(5), Harikanth Venkannagari(4), Ossi Turunen(3)