Matthijs K. C. Hesselink

Maastricht University Medical Centre — Netherlands

Medicine · Health Sciences

71h-index16.7kcitations270works5.82yr avg
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Research Topics

Adipose Tissue and Metabolism(158), Muscle metabolism and nutrition(90), Diet and metabolism studies(50), Lipid metabolism and biosynthesis(41), Mitochondrial Function and Pathology(37)

Publications270 total

ATGL-mediated lipolysis is essential for myocellular mitochondrial function, mitochondria-lipid droplet interaction and mitochondrial network connectivity
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids·2025Open Access
Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in patients with type 2 diabetes
Diabetes Obesity and Metabolism·2025· 5 citedOpen Access
Author response for "Carnitine supplementation improves insulin sensitivity and skeletal muscle acetylcarnitine formation in patients with type 2 diabetes"
2025
Therapeutic Potential of STE20-Type Kinase STK25 Inhibition for the Prevention and Treatment of Metabolically Induced Hepatocellular Carcinoma
Cellular and Molecular Gastroenterology and Hepatology·2025Open Access
Cold acclimation with shivering improves metabolic health in adults with overweight or obesity
Nature Metabolism·2024· 9 citedOpen Access
ATGL-mediated lipolysis is essential for myocellular mitochondrial function and augments PPARδ-induced improvements in mitochondrial respiration
2024Open Access
Development of a 31P magnetic resonance spectroscopy technique to quantify NADH and NAD+ at 3 T
Nature Communications·2024· 8 citedOpen Access
De effecten van een PPAR-α-agonist (ciprofibraat) op de weefselspecifieke glucoseopname in insulineresistentie; resultaten van een gerandomiseerde dubbelblinde placebogecontroleerde cross-overstudie
Nederlands Tijdschrift voor Diabetologie·2024Open Access
Empagliflozin prevents heart failure through inhibition of the NHE1-NO pathway, independent of SGLT2
Basic Research in Cardiology·2024· 30 citedOpen Access
The impact of prolonged fasting on 24h energy metabolism and its 24h rhythmicity in healthy, lean males: A randomized cross-over trial
Clinical Nutrition·2023· 16 citedOpen Access
The tissue‐specific metabolic effects of the <scp>PPARα</scp> agonist ciprofibrate in insulin‐resistant male individuals: a double‐blind, randomized, placebo‐controlled crossover study
Obesity·2023· 4 citedOpen Access
Invasive and noninvasive markers of human skeletal muscle mitochondrial function
Physiological Reports·2023· 10 citedOpen Access
PCr/ATP ratios and mitochondrial function in the heart. A comparative study in humans
Scientific Reports·2023· 14 citedOpen Access
Twenty-four hour rhythmicity in mitochondrial network connectivity and mitochondrial respiration; a study in human skeletal muscle biopsies of young lean and older individuals with obesity
Molecular Metabolism·2023· 17 citedOpen Access
Effect of β2-agonist treatment on insulin-stimulated peripheral glucose disposal in healthy men in a randomised placebo-controlled trial
Nature Communications·2023· 13 citedOpen Access
Divergent remodeling of the skeletal muscle metabolome over 24 h between young, healthy men and older, metabolically compromised men
Cell Reports·2022· 13 citedOpen Access
Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans
JCI Insight·2022· 10 citedOpen Access
Timing of physical activity in relation to liver fat content and insulin resistance
Diabetologia·2022· 77 citedOpen Access
Effects of SGLT2 inhibitor dapagliflozin in patients with type 2 diabetes on skeletal muscle cellular metabolism
Molecular Metabolism·2022· 42 citedOpen Access
Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary
GeroScience·2022· 34 citedOpen Access
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Frequent Co-authors

Patrick Schrauwen(40), Gert Schaart(17), Vera B. Schrauwen‐Hinderling(14), Joris Hoeks(11), Sander Kersten(10), Esther Moonen‐Kornips(10), Esther Phielix(8), Marco Mensink(7), Ruth C. R. Meex(6), Wim H. M. Saris(6), Lauren M. Sparks(6), Tineke van de Weijer(5), Johanna A. Jörgensen(5), M. Eline Kooi(5), Bas Havekes(4), Aaron P. Russell(4), Madeleen Bosma(4), Silvie Timmers(3), Wouter D. van Marken Lichtenbelt(3), Bart Staels(3)