Loretha Myers

Johns Hopkins University — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index8.7kcitations22works0.02yr avg
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Research Topics

Connective tissue disorders research(20), Aortic Disease and Treatment Approaches(10), Aortic aneurysm repair treatments(5), Cardiac Valve Diseases and Treatments(3), Protease and Inhibitor Mechanisms(2)

Publications22 total

Nonmyocyte ERK1/2 signaling contributes to load-induced cardiomyopathy in Marfan mice
JCI Insight·2017· 52 citedOpen Access
A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome
eLife·2015· 113 citedOpen Access
Author response: A deleterious gene-by-environment interaction imposed by calcium channel blockers in Marfan syndrome
2015· 1 citedOpen Access
Mutations in a TGF-β Ligand, TGFB3, Cause Syndromic Aortic Aneurysms and Dissections
Journal of the American College of Cardiology·2015· 290 citedOpen Access
Abstract 18126: Calcium Channel Blockers Accelerate Aortic Aneurysm and Cause Premature Lethality in Marfan Syndrome and Related Conditions
2014· 1 cited
The SMAD-binding domain of SKI: a hotspot for de novo mutations causing Shprintzen–Goldberg syndrome
European Journal of Human Genetics·2014· 59 citedOpen Access
Angiotensin II–dependent TGF-β signaling contributes to Loeys-Dietz syndrome vascular pathogenesis
Journal of Clinical Investigation·2013· 245 citedOpen Access
TGFβ Receptor Mutations Impose a Strong Predisposition for Human Allergic Disease
Science Translational Medicine·2013· 216 citedOpen Access
Su1829 Mutations in TGFβR1 and 2 Are Associated With Food Allergy, Eosinophilic Gastrointestinal Disease, and Inflammatory Bowel Disease
Gastroenterology·2013
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm
Nature Genetics·2012· 454 citedOpen Access
The Haploinsufficient <i>Col3a1</i> Mouse as a Model for Vascular Ehlers-Danlos Syndrome
Veterinary Pathology·2010· 47 citedOpen Access
Perturbations of Vascular Homeostasis and Aortic Valve Abnormalities in Fibulin-4 Deficient Mice
Circulation Research·2007· 154 citedOpen Access
Losartan in Marfan Syndrome—Beyond Blood Pressure Lowering
Journal of the American Society of Nephrology·2006· 4 cited
Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome
Science·2006· 1.8k citedOpen Access
A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2
Nature Genetics·2005· 1.8k cited
Toward an Understanding of Dural Ectasia: A Light Microscopy Study in a Murine Model of Marfan Syndrome
Spine·2005· 59 cited
TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome
Journal of Clinical Investigation·2004· 518 cited
TGF-β–dependent pathogenesis of mitral valve prolapse in a mouse model of Marfan syndrome
Journal of Clinical Investigation·2004· 478 citedOpen Access
Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome
Journal of Clinical Investigation·2004· 394 cited
Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome
Journal of Clinical Investigation·2004· 367 citedOpen Access
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Frequent Co-authors

Harry C. Dietz(21), Daniel P. Judge(13), Djahida Bedja(8), David L. Huso(8), Jennifer Habashi(6), Bart Loeys(6), Mark E. Lindsay(5), Gretchen Oswald(5), Alexander Doyle(5), Enid Neptune(4), Marc K. Halushka(4), Francesco Ramirez(4), Jefferson J. Doyle(4), Tammy M. Holm(3), Timothy K. Cooper(3), Megan Podowski(3), Lynn Y. Sakai(3), Kathleen L. Gabrielson(3), Elena Gallo(3), Jennifer E. Van Eyk(3)