Rafael Mira-y-Lopez

Icahn School of Medicine at Mount Sinai — United States

Biochemistry, Genetics and Molecular Biology · Life Sciences

18h-index933citations26works0.02yr avg
OpenAlex↗Google Scholar↗Lab page↗

Accepting Students?

No reports yet. Know if this professor is taking students?

Research Topics

Retinoids in leukemia and cellular processes(18), Estrogen and related hormone effects(12), Protease and Inhibitor Mechanisms(7), Antioxidant Activity and Oxidative Stress(5), Ubiquitin and proteasome pathways(4)

Publications26 total

Adipocyte derived paracrine mediators of mammary ductal morphogenesis controlled by retinoic acid receptors
Developmental Biology·2010· 12 cited
Mechanism of inhibition of MMTV-neu and MMTV-wnt1 induced mammary oncogenesis by RARα agonist AM580
Oncogene·2010· 32 cited
Effect of the all trans retinoic acid (ATRA) on the differentiation, invasion and growth, in 3D culture and in vivo, of the murine mammary cell lines LM38. (FIRCA R03 TW007207)
Cancer Research·2007
Dominant negative retinoic acid receptor initiates tumor formation in mice
Molecular Cancer·2006· 21 citedOpen Access
Expression of estrogen receptor α, retinoic acid receptor α and cellular retinoic acid binding protein II genes is coordinately regulated in human breast cancer cells
Oncogene·2005· 62 cited
Cellular retinol-binding protein-I inhibits PI3K/Akt signaling through a retinoic acid receptor-dependent mechanism that regulates p85–p110 heterodimerization
Oncogene·2004· 54 cited
Epigenetic CRBP downregulation appears to be an evolutionarily conserved (human and mouse) and oncogene-specific phenomenon in breast cancer.
Molecular Cancer·2004· 29 citedOpen Access
Retinoic acid receptor alpha2 is a growth suppressor epigenetically silenced in MCF-7 human breast cancer cells.
PubMed·2002· 41 cited
CRBP suppresses breast cancer cell survival and anchorage-independent growth
Oncogene·2001· 53 cited
Retinol conversion to retinoic acid is impaired in breast cancer cell lines relative to normal cells
Journal of Cellular Physiology·2000· 83 cited
Methylation of conserved CpG sites neighboring the beta retinoic acid response element may mediate retinoic acid receptor beta gene silencing in MCF-7 breast cancer cells
Oncogene·2000· 60 cited
Cellular Retinol-Binding Protein Expression and Breast Cancer
JNCI Journal of the National Cancer Institute·2000· 108 cited
Synergistic transcriptional activation of the mouse urokinase plasminogen activator (uPA) gene and of its enhancer activator protein 1 (AP1) site by cAMP and retinoic acid
Biochemical Journal·1998· 7 citedOpen Access
Laminin and estradiol regulation of the plasminogen-activator system in MCF-7 breast-carcinoma cells
International Journal of Cancer·1998· 11 citedOpen Access
The cellular retinoic acid binding protein II is a positive regulator of retinoic acid signaling in breast cancer cells.
PubMed·1997· 68 cited
Human breast carcinoma slice cultures retain retinoic acid sensitivity.
PubMed·1996· 7 cited
Defective expression of cellular retinol binding protein type 1 and retinoic acid receptors α2, β2, and ǵ2 in human breast cancer cells
The FASEB Journal·1996· 36 cited
Upregulation of cytokeratins 8 and 18 in human breast cancer T47D cells is retinoid-specific and retinoic acid receptor-dependent
Differentiation·1996· 41 cited
Redundant regulation of urokinase plasminogen activator transcription by the two major isozymes of cAMP-dependent protein kinase
Journal of Biological Chemistry·1992· 4 citedOpen Access
Estradiol modulation of plasminogen activator production in organ cultures of human breast carcinomas: Correlation with clinical outcome of anti‐estrogen therapy
International Journal of Cancer·1991· 18 cited
page 1 of 2Next →

Frequent Co-authors

Yongkui Jing(7), Liliana Ossowski(7), Eduardo Farias(6), Yuvarani S Kuppumbatti(5), Samuel Waxman(5), Ira J. Bleiweiss(3), Shigeo Nakajo(3), Alice Arapshian(3), Brent N. Rexer(2), Kazuyasu Nakaya(2), E. Reich(2), Arthur Zelent(2), Silvina Bertran(2), Tara S. Kupumbati(2), Christine V. Marzan(2), Silvia JARAMILLO(2), Susannah Waxman(2), John Mandeli(1), Wen Zheng(1), David E. Ong(1)