Tim Clausen

Research Institute of Molecular Pathology — Austria

Materials Science · Physical Sciences

55h-index10.3kcitations272works5.22yr avg
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Research Topics

Enzyme Structure and Function(66), Ubiquitin and proteasome pathways(50), Bacterial Genetics and Biotechnology(27), Protein Structure and Dynamics(26), Heat shock proteins research(22)

Publications272 total

<i>In vivo</i> CRISPR/Cas9 screens identify new regulators of B cell activation and plasma cell differentiation
The Journal of Experimental Medicine·2026· 1 citedOpen Access
PARG regulates the proteasomal degradation of TARG1
Cell Reports·2026Open Access
Structural basis for substrate recruitment and catalytic ubiquitin transfer by the E2/E3 hybrid enzyme UBE2O
Journal of Biological Chemistry·2025Open Access
Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants
Developmental Cell·2025· 1 citedOpen Access
ClpC1 Modulating Ohmyungsamycin A and Ecumicin Natural Product Analogues are Potent Antimycobacterials
ACS Infectious Diseases·2025· 1 cited
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
Science·2025· 6 citedOpen Access
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles
Cell·2025· 4 citedOpen Access
ATP functions as a pathogen-associated molecular pattern to activate the E3 ubiquitin ligase RNF213
Nature Communications·2025· 5 citedOpen Access
TRIM52 maintains cellular fitness and is under tight proteolytic control by multiple giant E3 ligases
Nature Communications·2025· 2 citedOpen Access
Protein waste turned into antibiotics as a defence strategy of human cells
Nature·2025
Cryo-EM micrographs of purified human BIRC6 in presence of MAP1LC3B
EMPIAR dataset·2025Open Access
A fluorescent folding reporter uncovers myosin misfolding as a driver of Hypertrophic Cardiomyopathy
2025Open Access
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase
Molecular Cell·2025· 8 citedOpen Access
Mouse RNF213 coupled to a UBE2L3 activity-based probe in presence of ATPγS
EMPIAR dataset·2025Open Access
Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control
2024· 3 citedOpen Access
Antimycobacterial cyclic peptide natural products bind and dysregulate stress response chaperones
2024Open Access
Author Correction: PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
The EMBO Journal·2024· 1 citedOpen Access
Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants
2024· 2 citedOpen Access
Convergence of orphan quality control pathways at a ubiquitin chain-elongating ligase
2024· 2 citedOpen Access
UNC-45 assisted myosin folding depends on a conserved FX3HY motif implicated in Freeman Sheldon Syndrome
Nature Communications·2024· 5 citedOpen Access
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Frequent Co-authors

Michael Ehrmann(18), Robert Huber(14), Markus Kaiser(9), T. Krojer(9), R Kurzbauer(7), Justyna Sawa‐Makarska(6), Karl Mechtler(6), Anton Meinhart(5), Alexander Heuck(4), Albrecht Messerschmidt(4), Corinna Wilken(3), Sandra Grau(3), Melisa Merdanovic(3), Bernd Laber(3), Klaus Rumpel(3), Alexander Schleiffer(3), Peter Macheroux(3), Clemens Steegborn(3), M.C. Wahl(3), Patrick Hauske(3)