Yungen Xu

Nantong University — China

Medicine · Health Sciences

34h-index3.4kcitations188works5.32yr avg
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Research Topics

PARP inhibition in cancer therapy(19), Catalytic C–H Functionalization Methods(17), Alzheimer's disease research and treatments(11), Synthesis and biological activity(11), Protein Degradation and Inhibitors(10)

Publications188 total

Discovery of 5-fluoro-aminopyrimidine derivatives as dual BTK/FLT3 inhibitors for the treatment of rheumatoid arthritis
Molecular Diversity·2026
Discovery of a spirocyclic influenza RNA-dependent RNA polymerase inhibitor
Bioorganic Chemistry·2025
PARP7: an Emerging Therapeutic Target-Insights into Biological Functions and Advances in Small-Molecule Inhibitor Development
Journal of Medicinal Chemistry·2025
Characterization of Protein–Ligand Chalcogen Bonds: Insights from Database Survey and Quantum Mechanics Calculations
Journal of Chemical Information and Modeling·2025· 2 cited
MDM2 Degrader as a Promising Therapeutic Strategy for Cancer Treatment
Journal of Medicinal Chemistry·2025· 2 cited
Discovery of Orally Potent Small-Molecule CD73 Inhibitor for Cancer Immunotherapy
Journal of Medicinal Chemistry·2025
Discovery and Optimization of Potent and Highly Selective PARP14 Inhibitors for the Treatment of Atopic Dermatitis
Journal of Medicinal Chemistry·2025· 3 cited
Discovery of novel JAK3 inhibitors for the treatment of atopic dermatitis
Bioorganic & Medicinal Chemistry Letters·2025
Discovery and Optimization of Novel Apo-IDO1 Inhibitors by a Pharmacophore-Based Structural Simplification Strategy
Journal of Medicinal Chemistry·2025· 6 cited
Parps in immune response: Potential targets for cancer immunotherapy
Biochemical Pharmacology·2025· 9 cited
Design, synthesis, and antitumor evaluation of triazolopyridine derivatives as novel inhibitors for BRD4
European Journal of Medicinal Chemistry·2025· 5 cited
Discovery of Novel Jak3 Inhibitors for the Treatment of Atopic Dermatitis
SSRN Electronic Journal·2025Open Access
New TIPARP inhibitor rescues mitochondrial function and brain injury in ischemic stroke
Pharmacological Research·2024· 8 citedOpen Access
Discovery of cyanoguanidine derivatives as biased μ-opioid receptor agonists
Bioorganic & Medicinal Chemistry·2024· 2 cited
Design, synthesis, and antitumor activity evaluation of 1,2,3-triazole derivatives as potent PD-1/PD-L1 inhibitors
Bioorganic Chemistry·2024· 5 cited
Discovery of highly potent PARP7 inhibitors for cancer immunotherapy
Bioorganic Chemistry·2024· 6 cited
Discovery of novel EGFR-PROTACs capable of degradation of multiple EGFR-mutated proteins
European Journal of Medicinal Chemistry·2024· 13 cited
Rational Design of PARP1/c-Met Dual Inhibitors for Overcoming PARP1 Inhibitor Resistance Induced by c-Met Overexpression
Journal of Medicinal Chemistry·2024· 23 citedOpen Access
Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy
Journal of Medicinal Chemistry·2024· 14 citedOpen Access
Discovery of the first ataxia telangiectasia and Rad3-related (ATR) degraders for cancer treatment
European Journal of Medicinal Chemistry·2024· 13 citedOpen Access
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Frequent Co-authors

Qihua Zhu(22), Jian Yang(7), Chongzhao Ran(6), Yi Zou(6), Lei Shi(4), Yiran Ge(4), Kewen Peng(4), Yuyan Li(4), Zhaoxing Chu(4), Shihui Huang(4), Dezhong Ji(3), Ting-Ting Wu(3), Jia‐Yu Xue(3), Junwei Wang(3), Guangchao He(3), Diliang Guo(3), Deju Ye(3), Hong Liu(3), Shiqi Wu(3), Xiaoming Zha(3)