Giovanni Stracquadanio

Biochemistry, Genetics and Molecular Biology · Life Sciences

23h-index3.5kcitations135works5.82yr avg
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Research Topics

RNA and protein synthesis mechanisms(29), CRISPR and Genetic Engineering(20), Fungal and yeast genetics research(18), Genomics and Phylogenetic Studies(13), Microbial Metabolic Engineering and Bioproduction(13)

Publications135 total

Engineering low immunogenic enzyme replacement therapies for Fabry disease
Molecular Genetics and Metabolism·2026
Production and characterisation of a functional recombinant human palmitoyl-protein thioesterase 1 in K. phaffii for the treatment of CLN1
Molecular Genetics and Metabolism·2026
APEX: Automated Protein EXpression in <i>Escherichia coli</i>
ACS Synthetic Biology·2025Open Access
GNN-Suite: a Graph Neural Network Benchmarking Framework for Biomedical Informatics
arXiv (Cornell University)·2025Open Access
Next-generation, engineered enzyme replacement therapies for Fabry disease
Molecular Genetics and Metabolism·2025
Construction and iterative redesign of synXVI a 903 kb synthetic Saccharomyces cerevisiae chromosome
Nature Communications·2025· 15 citedOpen Access
Protein engineering using variational free energy approximation
Nature Communications·2024· 6 citedOpen Access
Dirichlet latent modelling enables effective learning and sampling of the functional protein design space
Nature Communications·2024· 1 citedOpen Access
APEX: Automated Protein EXpression in <i>Escherichia coli</i>
2024Open Access
Synthetic genome modules designed for programmable silencing of functions and chromosomes
2024· 3 citedOpen Access
Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors
Leukemia·2024· 34 citedOpen Access
Biofoundry-Scale DNA Assembly Validation Using Cost-Effective High-Throughput Long-Read Sequencing
ACS Synthetic Biology·2024· 11 citedOpen Access
Manipulating the 3D organization of the largest synthetic yeast chromosome
Molecular Cell·2023· 33 citedOpen Access
Consequences of a telomerase-related fitness defect and chromosome substitution technology in yeast synIX strains
Cell Genomics·2023· 18 citedOpen Access
Synthetic chromosome fusion: Effects on mitotic and meiotic genome structure and function
Cell Genomics·2023· 21 citedOpen Access
Establishing chromosomal design-build-test-learn through a synthetic chromosome and its combinatorial reconfiguration
Cell Genomics·2023· 20 citedOpen Access
Debugging and consolidating multiple synthetic chromosomes reveals combinatorial genetic interactions
Cell·2023· 89 citedOpen Access
Parallel laboratory evolution and rational debugging reveal genomic plasticity to S. cerevisiae synthetic chromosome XIV defects
Cell Genomics·2023· 20 citedOpen Access
Context-dependent neocentromere activity in synthetic yeast chromosome VIII
Cell Genomics·2023· 23 citedOpen Access
Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics
Cell Genomics·2023· 31 citedOpen Access
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Frequent Co-authors

Jef D. Boeke(23), Joel S. Bader(22), Leslie A. Mitchell(20), Yizhi Cai(16), Giuseppe Nicosia(14), Kun Yang(12), Viola Fanfani(10), Roy Walker(9), Yu Zhao(9), Jitong Cai(8), Neta Agmon(7), Weimin Zhang(7), Stephanie Lauer(7), Karen Zeller(6), Junbiao Dai(6), Sarah M. Richardson(5), James A. Martin(5), Yue Shen(5), Gareth L. Bond(5), Luciana Lazar‐Stefanita(5)